Pulmonary effects of body position, PEEP, and surfactant depletion in dogs

A. Larsson, J. T. Gilbert, L. Bunegin, J. Gelineau, R. B. Smith

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The influence of position (sphinx, lateral, supine), surfactant depletion, and different positive end‐expiratory pressure (PEEP) on functional residual capacity (FRC), series dead space (VdS) and compliance of the respiratory system (Crs) were evaluated in five dogs. Ventilation homogeneity as measured by an index (multiple breath alveolar mixing efficiency), oxygenation, and cardiovascular hemodynamics were additionally examined. The dogs were anesthetized with halothane, paralyzed, and mechanically ventilated. FRC and VdS were found to be notably large in dogs, 45 ± 8 ml/kg and 6 ± 1 ml/kg, respectively. FRC and ventilation homogeneity were improved in the sphinx position (prone position with upright head). Surfactant depletion by lung lavage with 37±C saline caused an immediate and stable decrease in FRC, Crs, and oxygenation (P<0.05, respectively) for about 5 h without marked effects on the circulatory system. FRC and VdS increased with increasing PEEP. At the highest PEEP, 10 cmH2O (1 kPa), Crs decreased (P<0.05) and ventilation became more uneven, indicating alveolar overdistension.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalActa Anaesthesiologica Scandinavica
Volume36
Issue number1
DOIs
StatePublished - Jan 1992

Keywords

  • Dogs
  • functional residual capacity
  • gas distribution
  • lung function
  • lung surfactant depletion
  • positive end‐expiratory pressure
  • respiratory dead space

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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