Pulmonary effects of body position, PEEP, and surfactant depletion in dogs

A. Larsson, J. T. Gilbert, Leonid Bunegin, J. Gelineau, R. B. Smith

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The influence of position (sphinx, lateral, supine), surfactant depletion, and different positive end-expiratory pressure (PEEP) on functional residual capacity (FRC), series dead space (V(d)S) and compliance of the respiratory system (C(rs)) were evaluated in five dogs. Ventilation homogeneity as measured by an index (multiple breath alveolar mixing efficiency), oxygenation, and cardiovascular hemodynamics were additionally examined. The dogs were anesthetized with halothane, paralyzed, and mechanically ventilated. FRC and V(d)S were found to be notably large in dogs, 45 ± 8 ml/kg and 6 ± 1 ml/kg, respectively. FRC and ventilation homogeneity were improved in the sphinx position (prone position with upright head). Surfactant depletion by lung lavage with 37°C saline caused an immediate and stable decrease in FRC, C(rs), and oxygenation (P < 0.05, respectively) for about 5 h without marked effects on the circulatory sytem. FRC and V(d)S increased with increasing PEEP. At the highest PEEP, 10 cmH2O (1 kPa), C(rs) decreased (P < 0.05) and ventilation became more uneven, indicating alveolar overdistension.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalActa Anaesthesiologica Scandinavica
Volume36
Issue number1
StatePublished - 1992

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Functional Residual Capacity
Positive-Pressure Respiration
Surface-Active Agents
Dogs
Lung
Respiratory System
Compliance
Ventilation
Prone Position
Bronchoalveolar Lavage
Halothane
Hemodynamics
Head

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Larsson, A., Gilbert, J. T., Bunegin, L., Gelineau, J., & Smith, R. B. (1992). Pulmonary effects of body position, PEEP, and surfactant depletion in dogs. Acta Anaesthesiologica Scandinavica, 36(1), 38-45.

Pulmonary effects of body position, PEEP, and surfactant depletion in dogs. / Larsson, A.; Gilbert, J. T.; Bunegin, Leonid; Gelineau, J.; Smith, R. B.

In: Acta Anaesthesiologica Scandinavica, Vol. 36, No. 1, 1992, p. 38-45.

Research output: Contribution to journalArticle

Larsson, A, Gilbert, JT, Bunegin, L, Gelineau, J & Smith, RB 1992, 'Pulmonary effects of body position, PEEP, and surfactant depletion in dogs', Acta Anaesthesiologica Scandinavica, vol. 36, no. 1, pp. 38-45.
Larsson, A. ; Gilbert, J. T. ; Bunegin, Leonid ; Gelineau, J. ; Smith, R. B. / Pulmonary effects of body position, PEEP, and surfactant depletion in dogs. In: Acta Anaesthesiologica Scandinavica. 1992 ; Vol. 36, No. 1. pp. 38-45.
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