Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers

Wojciech R. Dolliver, Wei Wang, Pietro Nardelli, Farbod N. Rahaghi, Jose L. Orejas, Diego J. Maselli, Andrew Yen, Kendra Young, Gregory Kinney, Raul San José Estépar, Alejandro A. Diaz

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of small pulmonary arteries measured as the ratio of blood vessel volume in arteries <5 mm2 in cross-section to total arterial blood vessel volume (BV5a/TBVa), with lower values indicating more pruning, was associated with 5-yr progressing CT-derived bronchiectasis in smokers (Odds Ratio (OR) [95% Confidence interval], 1.28 [1.07–1.53] per 5% lower BV5a/TBVa, P = 0.007). Corresponding results in smokers with COPD were: OR 1.45 [1.11–1.89] per 5% lower BV5a/TBVa, P = 0.007. The results support a vascular factor for structural progression of bronchiectasis.

Original languageEnglish (US)
Article number106971
JournalRespiratory Medicine
Volume202
DOIs
StatePublished - Oct 2022
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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