Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers

Wojciech R. Dolliver; Wei Wang; Pietro Nardelli; Farbod N. Rahaghi; Jose L. Orejas; Diego J. Maselli; Andrew Yen; Kendra Young; Gregory Kinney; Raul San José Estépar; Alejandro A. Diaz

doi:10.1016/j.rmed.2022.106971

Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers

Wojciech R. Dolliver, Wei Wang, Pietro Nardelli, Farbod N. Rahaghi, Jose L. Orejas, Diego J. Maselli, Andrew Yen, Kendra Young, Gregory Kinney, Raul San José Estépar, Alejandro A. Diaz

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Loss of small pulmonary arteries measured as the ratio of blood vessel volume in arteries <5 mm² in cross-section to total arterial blood vessel volume (BV5a/TBVa), with lower values indicating more pruning, was associated with 5-yr progressing CT-derived bronchiectasis in smokers (Odds Ratio (OR) [95% Confidence interval], 1.28 [1.07–1.53] per 5% lower BV5a/TBVa, P = 0.007). Corresponding results in smokers with COPD were: OR 1.45 [1.11–1.89] per 5% lower BV5a/TBVa, P = 0.007. The results support a vascular factor for structural progression of bronchiectasis.

Original language	English (US)
Article number	106971
Journal	Respiratory Medicine
Volume	202
DOIs	https://doi.org/10.1016/j.rmed.2022.106971
State	Published - Oct 2022
Externally published	Yes

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1016/j.rmed.2022.106971

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@article{a67bd4f6e27c46c1afddd5e5cca84647,

title = "Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers",

abstract = "Loss of small pulmonary arteries measured as the ratio of blood vessel volume in arteries <5 mm2 in cross-section to total arterial blood vessel volume (BV5a/TBVa), with lower values indicating more pruning, was associated with 5-yr progressing CT-derived bronchiectasis in smokers (Odds Ratio (OR) [95% Confidence interval], 1.28 [1.07–1.53] per 5% lower BV5a/TBVa, P = 0.007). Corresponding results in smokers with COPD were: OR 1.45 [1.11–1.89] per 5% lower BV5a/TBVa, P = 0.007. The results support a vascular factor for structural progression of bronchiectasis.",

author = "Dolliver, {Wojciech R.} and Wei Wang and Pietro Nardelli and Rahaghi, {Farbod N.} and Orejas, {Jose L.} and Maselli, {Diego J.} and Andrew Yen and Kendra Young and Gregory Kinney and Est{\'e}par, {Raul San Jos{\'e}} and Diaz, {Alejandro A.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = oct,

doi = "10.1016/j.rmed.2022.106971",

language = "English (US)",

volume = "202",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "W.B. Saunders Ltd",

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TY - JOUR

T1 - Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers

AU - Dolliver, Wojciech R.

AU - Wang, Wei

AU - Nardelli, Pietro

AU - Rahaghi, Farbod N.

AU - Orejas, Jose L.

AU - Maselli, Diego J.

AU - Yen, Andrew

AU - Young, Kendra

AU - Kinney, Gregory

AU - Estépar, Raul San José

AU - Diaz, Alejandro A.

PY - 2022/10

Y1 - 2022/10

N2 - Loss of small pulmonary arteries measured as the ratio of blood vessel volume in arteries <5 mm2 in cross-section to total arterial blood vessel volume (BV5a/TBVa), with lower values indicating more pruning, was associated with 5-yr progressing CT-derived bronchiectasis in smokers (Odds Ratio (OR) [95% Confidence interval], 1.28 [1.07–1.53] per 5% lower BV5a/TBVa, P = 0.007). Corresponding results in smokers with COPD were: OR 1.45 [1.11–1.89] per 5% lower BV5a/TBVa, P = 0.007. The results support a vascular factor for structural progression of bronchiectasis.

AB - Loss of small pulmonary arteries measured as the ratio of blood vessel volume in arteries <5 mm2 in cross-section to total arterial blood vessel volume (BV5a/TBVa), with lower values indicating more pruning, was associated with 5-yr progressing CT-derived bronchiectasis in smokers (Odds Ratio (OR) [95% Confidence interval], 1.28 [1.07–1.53] per 5% lower BV5a/TBVa, P = 0.007). Corresponding results in smokers with COPD were: OR 1.45 [1.11–1.89] per 5% lower BV5a/TBVa, P = 0.007. The results support a vascular factor for structural progression of bronchiectasis.

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DO - 10.1016/j.rmed.2022.106971

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AN - SCOPUS:85138065311

SN - 0954-6111

VL - 202

JO - Respiratory Medicine

JF - Respiratory Medicine

M1 - 106971

ER -

Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers

Abstract

ASJC Scopus subject areas

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