Pulmonary alveolar proteinosis: The diagnosis by segmental lavage

R. J. Martin, J. J. Coalson, R. M. Rogers, F. O. Horton, L. E. Manous

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Histologic findings from segmental lavage material via the fiberoptic bronchoscope were evaluated as a means of diagnosing pulmonary alveolar proteinosis. Active cases of alveolar proteinosis yielded grossly opaque and/or milky effluents. The unique histologic findings in alveolar proteinosis included: (1) very few alveolar macrophages (2) large acellular eosinophilic bodies in a diffuse background of eosinophilic granules, and (3) periodic acid-Schiff staining of the proteinaceous material with a lack of significant alcian blue staining. Thus, the diagnosis of pulmonary alveolar proteinosis can be made by evaluation of the clinical setting and histologic findings of the effluent material from a segmental lavage.

Original languageEnglish (US)
Pages (from-to)819-825
Number of pages7
JournalAmerican Review of Respiratory Disease
Issue number5
StatePublished - Jun 27 1980

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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