Puberty, gonadal steroids and fertility: Potential reproductive markers of aging

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8 Scopus citations

Abstract

Three potential predictors (i.e., biomarkers) of longevity in mammals are proposed: (1) age of pubertal onset, (2) concentrations of gonodal steroids and (3) timing of age-related infertility. Ages of pubertal onset and declining fertility are hypothesized to be positively correlated with longevity. Concentrations of androgens and estrogens are proposed to be inversely and positively correlated, respectively, with life span. Evidence upon which these hypotheses are based is reviewed and its limitations are discussed. General strategies for testing these hypotheses are outlined. In addition, several pragmatic as well as theoretical issues facing research on biomarkers of aging are discussed, using specific examples derived from studies of female reproductive aging.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalExperimental Gerontology
Volume23
Issue number4-5
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • androgen
  • biomarkers of aging
  • estrogen
  • fertility
  • puberty

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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