Psychopharmacological treatment for cognitive impairment in survivors of traumatic brain injury: A critical review

Brian W. Writer, Jason E. Schillerstrom

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Traumatic brain injury (TBI) is a growing national health issue that commonly results in clinically significant cognitive impairments. This article reviews and evaluates the many proposed psychopharmacological treatments for TBI-related cognitive impairment. A literature review was utilized to focus on stimulant and nonstimulant dopamine enhancing agents, acetylcholinesterase inhibitors, antidepressant agents, mood stabilizers, antipsychotics, and benzodiazepines. The most consistent evidence supports the use of dopamine enhancing medications. However, other medications such as acetylcholinesterase inhibitors and antidepressant agents may help select subgroups. A need remains for well designed, sufficiently powered studies that incorporate functionally relevant neuropsychological outcome measures.

Original languageEnglish (US)
Pages (from-to)362-370
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume21
Issue number4
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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