Psychoneuroimmunology of Mood Disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Recent research has shed light on the intricate relationship between mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD), and inflammation. This chapter explores the complex interplay involving immune and metabolic dysfunction in the pathophysiology of these disorders, emphasizing their association with autoimmunity/inflammatory conditions, chronic low-grade systemic inflammation, T cell overactivation, and immunosenescence. This perspective underscores the notion that MDD and BD are not solely brain disorders, highlighting their nature as multi-system conditions.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press
Pages49-72
Number of pages24
DOIs
StatePublished - 2025

Publication series

NameMethods in Molecular Biology
Volume2868
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Bipolar disorder
  • Cytokines
  • Depression
  • Immunometabolism
  • Immunosenescence
  • Inflammation
  • Mood disorders

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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