Psychoneuroimmune Implications of Type 2 Diabetes: Redux

Jason C. O'Connor, Daniel R. Johnson, Gregory G. Freund

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


A sizable body of knowledge has arisen demonstrating that type 2 diabetes (T2D) is associated with alterations in the innate immune system. The resulting proinflammatory-leaning imbalance is implicated in the development of secondary disease complications and comorbidities, such as delayed wound healing, accelerated progress of atherosclerosis, and retinopathy, in people who have T2D. New experimental data and the results of recently published health-related quality-of-life surveys indicate that individuals who have T2D experience diminished feelings of happiness, well being, and satisfaction with life. These emotional and psychological consequences of T2D point to altered neuroimmunity as a previously unappreciated complication of T2D. This article discusses recent data detailing the impact of T2D on a person's PNI response.

Original languageEnglish (US)
Pages (from-to)339-358
Number of pages20
JournalImmunology and Allergy Clinics of North America
Issue number2
StatePublished - May 2009
Externally publishedYes


  • Cytokine
  • Fever
  • Inflammation
  • Insulin resistance
  • Macrophage
  • Mental health
  • Obesity
  • Sickness behavior

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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