Providing primary care for long-term survivors of childhood acute lymphoblastic leukemia

K. C. Oeffinger, D. A. Eshelman, G. E. Tomlinson, M. Tolle, G. W. Schneider

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Primary care physicians will be providing longitudinal health care for long-term survivors of childhood acute lymphoblastic leukemia (ALL) with increasing frequency. Late effects (sequelae) secondary to treatment with radiation or chemotherapeutic agents are frequent and may be serious. Depending on treatment exposures, this at-risk population may experience life-threatening late effects, such as cirrhosis secondary to hepatitis C or late-onset anthracycline-induced cardiomyopathy, or life-changing late effects, such as cognitive dysfunction. Many survivors of childhood ALL will develop problems such as obesity and osteopenia at a young age, which will significantly affect their risk for serious health outcomes as they grow older. The goal of our review is to assist primary care physicians in providing longitudinal health care for long-term survivors of childhood ALL. We also highlight areas needing further investigation, including the prevalence of different late effects, determination of risk factors associated with a late effect, a better understanding of the potential impact of late effects on the premature development of common adult health problems, and the value and timing of different tests for screening asymptomatic survivors.

Original languageEnglish (US)
Pages (from-to)1133-1146
Number of pages14
JournalJournal of Family Practice
Volume49
Issue number12
StatePublished - Dec 1 2000

Keywords

  • Acute
  • Late effects [non-MESH]
  • Leukemia
  • Lymphoblastic
  • Screening [non-MESH]
  • Survivors

ASJC Scopus subject areas

  • Family Practice

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