Proton pump inhibitors and clopidogrel: Is it a significant drug interaction?

Ola O. Oyetayo, Robert L. Talbert

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Importance of the field: Clopidogrel is indicated as part of a dual antiplatelet therapy (DAT) with aspirin for the prevention of cardiac related events in acute coronary syndromes particularly in patients undergoing percutaneous coronary intervention. Recently, there have been reports of a clinically significant drug interaction between clopidogrel and proton pump inhibitors (PPI), which are frequently co-prescribed to prevent DAT associated gastrointestinal (GI) bleeding. Areas covered in this review: This review evaluates the risk of GI bleeding associated with DAT and the rationale for the use of PPI. This review also describes the pharmacokinetic and pharmacodynamic basis for the interaction and evaluates its significance on clinical outcomes. An extensive literature search on PubMed from January 1980 to August 2009 was performed. Additionally, abstracts and presentations from key cardiology meetings and press releases were reviewed for relevant studies related to the interaction. What the reader will gain: At the end of the review, readers should have a complete understanding of the interaction and steps that can be taken to limit the interaction. Take home message: There is a mechanistic basis and pharmacodynamic data supporting an interaction between PPIs, particularly omeprazole and clopidogrel. The clinical significance of this interaction is, however, still a subject of intense debate and ongoing research.

Original languageEnglish (US)
Pages (from-to)593-602
Number of pages10
JournalExpert Opinion on Drug Safety
Issue number4
StatePublished - Jul 2010


  • P2Y12 inhibitors
  • PPIs
  • acute coronary syndromes
  • atherosclerosis
  • clopidogrel
  • drug interaction
  • dual antiplatelet therapy

ASJC Scopus subject areas

  • Pharmacology (medical)


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