Proton magnetic resonance spectroscopy in the brain: Report of AAPM MR Task Group #9

Dick J. Drost, William R. Riddle, Geoffrey D. Clarke

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


AAPM Magnetic Resonance Task Group #9 on proton magnetic resonance spectroscopy (MRS) in the brain was formed to provide a reference document for acquiring and processing proton (1H) MRS acquired from brain tissue. MRS is becoming a common adjunct to magnetic resonance imaging (MRI), especially for the differential diagnosis of tumors in the brain. Even though MR imaging is an offshoot of MR spectroscopy, clinical medical physicists familiar with MRI may not be familiar with many of the common practical issues regarding MRS. Numerous research laboratories perform in vivo MRS on other magnetic nuclei, such as 31P, 13C, and 19F. However, most commercial MR scanners are generally only capable of spectroscopy using the signals from protons. Therefore this paper is of limited scope, giving an overview of technical issues that are important to clinical proton MRS, discussing some common clinical MRS problems, and suggesting how they might be resolved. Some fundamental issues covered in this paper are common to many forms of magnetic resonance spectroscopy and are written as an introduction for the reader to these methods. These topics include shimming, eddy currents, spatial localization, solvent saturation, and post-processing methods. The document also provides an extensive review of the literature to guide the practicing medical physicist to resources that may be useful for dealing with issues not covered in the current article.

Original languageEnglish (US)
Pages (from-to)2177-2197
Number of pages21
JournalMedical physics
Issue number9
StatePublished - Sep 2002
Externally publishedYes


  • Brain metabolism
  • Magnetic resonance spectroscopy
  • Medical brain imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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