Protochordate allorecognition is controlled by a MHC-like gene system

V. L. Scofield, J. M. Schlumpberger, L. A. West, I. L. Weissman

Research output: Contribution to journalArticlepeer-review

305 Scopus citations


Colonial tunicates, unlike vertebrates, undergo transplantation in nature. Rejection or acceptance between colonies of Botryllus is controlled by a single gene locus with multiple alleles. The same genetic region apparently maintains this polymorphism by preventing fertilization between gametes sharing alleles. The Botryllus histocompatibility system may reflect the original adaptive function of ancestral MHC genes.

Original languageEnglish (US)
Pages (from-to)499-502
Number of pages4
Issue number5849
StatePublished - Dec 1 1982

ASJC Scopus subject areas

  • General


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