@article{64251f691df74651b978431c88c3a422,
title = "Proteomics and machine learning in the prediction and explanation of low pectoralis muscle area",
abstract = "Low muscle mass is associated with numerous adverse outcomes independent of other associated comorbid diseases. We aimed to predict and understand an individual{\textquoteright}s risk for developing low muscle mass using proteomics and machine learning. We identified eight biomarkers associated with low pectoralis muscle area (PMA). We built three random forest classification models that used either clinical measures, feature selected biomarkers, or both to predict development of low PMA. The area under the receiver operating characteristic curve for each model was: clinical-only = 0.646, biomarker-only = 0.740, and combined = 0.744. We displayed the heterogenetic nature of an individual{\textquoteright}s risk for developing low PMA and identified two distinct subtypes of participants who developed low PMA. While additional validation is required, our methods for identifying and understanding individual and group risk for low muscle mass could be used to enable developments in the personalized prevention of low muscle mass.",
author = "{OPDGene Study Consortium} and Enzer, {Nicholas A.} and Joe Chiles and Stefanie Mason and Toru Shirahata and Victor Castro and Elizabeth Regan and Bina Choi and Yuan, {Nancy F.} and Diaz, {Alejandro A.} and Washko, {George R.} and McDonald, {Merry Lynn} and Est{\'e}par, {Ra{\'u}l San Jos{\'e}} and Ash, {Samuel Y.} and Hanania, {Nicola A.} and Mustafa Atik and Laura Bertrand and Aladin Boriek and Thomas Monaco and Dharani Narendra and Francesca Polverino and {de Rosen}, {Veronica V.Lenge} and Salas, {Paula Sierra} and Wu, {Tianshi David} and DeMeo, {Dawn L.} and Hersh, {Craig P.} and Diaz, {Alejandro A.} and Gagne, {Staci M.} and Jacobson, {Francine L.} and Kathryn Marentette and Washko, {George R.} and Seth Wilson and Yun, {Jeong H.} and Barr, {R. Graham} and Austin, {John H.M.} and Blum, {Maria Lorena Gomez} and D{\textquoteright}Souza, {Belinda M.} and Emilay Florez and Valeria Lopez and Wanda Pecheco and Byron Thomashow and Wendt, {Chris H.} and Arianne Baldomero and Miranda Hassler and Kunisaki, {Ken M.} and David MacDonald and Charlene McEvoy and Nell Adams and Barbara Heinz and Antonio Anzueto and Adams, {Sandra G.}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
month = dec,
doi = "10.1038/s41598-024-68447-y",
language = "English (US)",
volume = "14",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}