Proteolytic susceptibility of membrane proteins during erythrocyte aging

Maria Gaczyńska; Janusz Rosin; Mirosław Soszyński; Grzegorz Bartosz

doi:10.1016/0047-6374(86)90002-3

Proteolytic susceptibility of membrane proteins during erythrocyte aging

Maria Gaczyńska, Janusz Rosin, Mirosław Soszyński, Grzegorz Bartosz

Molecular Medicine

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Susceptibility of membrane proteins to digestion with chymotrypsin was compared in various age fractions of bovine erythrocytes by SDS-polyacrylamide gel electrophoresis. The extent of protein digestion was found to be higher in membranes of older erythrocytes, as judged from the disappearance of original protein bands and accumulation of digestion products. These results are consistent with the hypothesis of a proteolytic generation of a "senescent cel antigen" in red blood cells.

Original language	English (US)
Pages (from-to)	109-121
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0047-6374(86)90002-3
Publication status	Published - Jul 1986

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Keywords

Erythrocyte aging
Membrane proteins
Proteolytic susceptibility

ASJC Scopus subject areas

Aging
Developmental Biology

Cite this

Gaczyńska, M., Rosin, J., Soszyński, M., & Bartosz, G. (1986). Proteolytic susceptibility of membrane proteins during erythrocyte aging. Mechanisms of Ageing and Development, 35(2), 109-121. https://doi.org/10.1016/0047-6374(86)90002-3

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10.1016/0047-6374(86)90002-3