Proteolytic susceptibility of membrane proteins during erythrocyte aging

Maria Gaczyńska, Janusz Rosin, Mirosław Soszyński, Grzegorz Bartosz

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Susceptibility of membrane proteins to digestion with chymotrypsin was compared in various age fractions of bovine erythrocytes by SDS-polyacrylamide gel electrophoresis. The extent of protein digestion was found to be higher in membranes of older erythrocytes, as judged from the disappearance of original protein bands and accumulation of digestion products. These results are consistent with the hypothesis of a proteolytic generation of a "senescent cel antigen" in red blood cells.

Original languageEnglish (US)
Pages (from-to)109-121
Number of pages13
JournalMechanisms of Ageing and Development
Volume35
Issue number2
DOIs
Publication statusPublished - Jul 1986

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Keywords

  • Erythrocyte aging
  • Membrane proteins
  • Proteolytic susceptibility

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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