Proteolytic activity of human erythrocyte membrane during ghosts preparation

Maria Gaczyńska, Grzegorz Bartosz

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

1. 1. Proteins in human erythrocyte membranes after red blood cells hemolysis revealed relatively high rate of self-digestion. 2. 2. This indicates hemolysis as a critical moment for membrane proteases activation. 3. 3. The detailed pattern of band 3 protein and spectrin degradation during ghosts preparation was more complicated and reflected both the changes in proteolytic susceptibility and extraction of some proteases. 4. 4. Further extraction of membrane proteins by alkali stripping resulted in an increase in the self-digestion rate and decrease in the degradation rate of an exogenous substrate.

Original languageEnglish (US)
Pages (from-to)1383-1385
Number of pages3
JournalInternational Journal of Biochemistry
Volume21
Issue number12
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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