Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle

P. Renee Yew, Marc W. Kirschner

Research output: Contribution to journalArticle

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Abstract

The cell division cycle gene, CDC34, is required for ubiquitin-mediated degradation of G1 regulators and cell cycle progression through the transition from G1 to S phase in budding yeast. A CDC34 requirement for S phase onset in higher eukaryotes has not been established. Studies of the simple embryonic cell cycle of Xenopus laevis eggs demonstrated that Cdc34p in a large molecular size complex was required in the initiation of DNA replication. Cdc34p appears to regulate the initiation function of Cdk2- cyclin E, perhaps through the degradation of the Xenopus cdk inhibitor, Xic1.

Original languageEnglish (US)
Pages (from-to)1672-1676
Number of pages5
JournalScience
Volume277
Issue number5332
DOIs
StatePublished - Sep 12 1997

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