Abstract
The cell division cycle gene, CDC34, is required for ubiquitin-mediated degradation of G1 regulators and cell cycle progression through the transition from G1 to S phase in budding yeast. A CDC34 requirement for S phase onset in higher eukaryotes has not been established. Studies of the simple embryonic cell cycle of Xenopus laevis eggs demonstrated that Cdc34p in a large molecular size complex was required in the initiation of DNA replication. Cdc34p appears to regulate the initiation function of Cdk2- cyclin E, perhaps through the degradation of the Xenopus cdk inhibitor, Xic1.
Original language | English (US) |
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Pages (from-to) | 1672-1676 |
Number of pages | 5 |
Journal | Science |
Volume | 277 |
Issue number | 5332 |
DOIs | |
State | Published - Sep 12 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General