Proteinase-mediated cartilage degradation in osteoarthritis

David D Dean

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

Original languageEnglish (US)
Pages (from-to)2-11
Number of pages10
JournalSeminars in Arthritis and Rheumatism
Volume20
Issue number6 SUPPL. 2
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Osteoarthritis
Cartilage
Peptide Hydrolases
Articular Cartilage
Therapeutics

Keywords

  • Cartilage degradation
  • matrix metalloproteinases
  • osteoarthritis
  • proteinases
  • tissue inhibitor of metalloproteinases (TIMP)

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Orthopedics and Sports Medicine
  • Rheumatology

Cite this

Proteinase-mediated cartilage degradation in osteoarthritis. / Dean, David D.

In: Seminars in Arthritis and Rheumatism, Vol. 20, No. 6 SUPPL. 2, 1991, p. 2-11.

Research output: Contribution to journalArticle

Dean, David D. / Proteinase-mediated cartilage degradation in osteoarthritis. In: Seminars in Arthritis and Rheumatism. 1991 ; Vol. 20, No. 6 SUPPL. 2. pp. 2-11.
@article{802738eb40914d39b106e89cce06f43d,
title = "Proteinase-mediated cartilage degradation in osteoarthritis",
abstract = "Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.",
keywords = "Cartilage degradation, matrix metalloproteinases, osteoarthritis, proteinases, tissue inhibitor of metalloproteinases (TIMP)",
author = "Dean, {David D}",
year = "1991",
doi = "10.1016/0049-0172(91)90023-S",
language = "English (US)",
volume = "20",
pages = "2--11",
journal = "Seminars in Arthritis and Rheumatism",
issn = "0049-0172",
publisher = "W.B. Saunders Ltd",
number = "6 SUPPL. 2",

}

TY - JOUR

T1 - Proteinase-mediated cartilage degradation in osteoarthritis

AU - Dean, David D

PY - 1991

Y1 - 1991

N2 - Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

AB - Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

KW - Cartilage degradation

KW - matrix metalloproteinases

KW - osteoarthritis

KW - proteinases

KW - tissue inhibitor of metalloproteinases (TIMP)

UR - http://www.scopus.com/inward/record.url?scp=0025897125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025897125&partnerID=8YFLogxK

U2 - 10.1016/0049-0172(91)90023-S

DO - 10.1016/0049-0172(91)90023-S

M3 - Article

C2 - 1866627

AN - SCOPUS:0025897125

VL - 20

SP - 2

EP - 11

JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

SN - 0049-0172

IS - 6 SUPPL. 2

ER -