Proteinase-mediated cartilage degradation in osteoarthritis

David D. Dean

doi:10.1016/0049-0172(91)90023-S

Proteinase-mediated cartilage degradation in osteoarthritis

David D. Dean

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

Original language	English (US)
Pages (from-to)	2-11
Number of pages	10
Journal	Seminars in Arthritis and Rheumatism
Volume	20
Issue number	6 SUPPL. 2
DOIs	https://doi.org/10.1016/0049-0172(91)90023-S
State	Published - Jun 1991
Externally published	Yes

Keywords

Cartilage degradation
matrix metalloproteinases
osteoarthritis
proteinases
tissue inhibitor of metalloproteinases (TIMP)

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Rheumatology

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10.1016/0049-0172(91)90023-S

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title = "Proteinase-mediated cartilage degradation in osteoarthritis",

abstract = "Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.",

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AB - Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

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KW - osteoarthritis

KW - proteinases

KW - tissue inhibitor of metalloproteinases (TIMP)

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ER -

Proteinase-mediated cartilage degradation in osteoarthritis

Abstract

Keywords

ASJC Scopus subject areas

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