Proteinase-mediated cartilage degradation in osteoarthritis

David D. Dean

Research output: Contribution to journalArticle

78 Scopus citations


Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

Original languageEnglish (US)
Pages (from-to)2-11
Number of pages10
JournalSeminars in Arthritis and Rheumatism
Issue number6 SUPPL. 2
Publication statusPublished - Jun 1991



  • Cartilage degradation
  • matrix metalloproteinases
  • osteoarthritis
  • proteinases
  • tissue inhibitor of metalloproteinases (TIMP)

ASJC Scopus subject areas

  • Rheumatology
  • Anesthesiology and Pain Medicine

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