Abstract
Blood protein interaction with prosthetic surfaces seems to be the initial step in the chain of events leading to tissue incorporation of endovascular devices. This paper focuses on the relationship between surface free energy and protein adsorption on metals and polymers commonly used for fabricating vascular prosthetic devices. Our results support a relationship between surface energy and protein adsorption. Albumin was more easily eluted than fibrinogen and fibronectin from most metals and all polymeric surfaces considered. Following elution, metals retained a larger fraction of protein as compared to polymers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 127-141 |
| Number of pages | 15 |
| Journal | Journal of Long-Term Effects of Medical Implants |
| Volume | 10 |
| Issue number | 1-2 |
| State | Published - 2000 |
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Keywords
- Artificial blood vessels
- Blood proteins
- Prosthetic vascular materials
- Stents
- Surface proteins
ASJC Scopus subject areas
- Biomedical Engineering
- Medicine (miscellaneous)
- Orthopedics and Sports Medicine
- Pathology and Forensic Medicine
Cite this
Protein interactions with endovascular prosthetic surfaces. / Simon, Cristina; Palmaz, Julio C; Sprague, Eugene A.
In: Journal of Long-Term Effects of Medical Implants, Vol. 10, No. 1-2, 2000, p. 127-141.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein interactions with endovascular prosthetic surfaces
AU - Simon, Cristina
AU - Palmaz, Julio C
AU - Sprague, Eugene A
PY - 2000
Y1 - 2000
N2 - Blood protein interaction with prosthetic surfaces seems to be the initial step in the chain of events leading to tissue incorporation of endovascular devices. This paper focuses on the relationship between surface free energy and protein adsorption on metals and polymers commonly used for fabricating vascular prosthetic devices. Our results support a relationship between surface energy and protein adsorption. Albumin was more easily eluted than fibrinogen and fibronectin from most metals and all polymeric surfaces considered. Following elution, metals retained a larger fraction of protein as compared to polymers.
AB - Blood protein interaction with prosthetic surfaces seems to be the initial step in the chain of events leading to tissue incorporation of endovascular devices. This paper focuses on the relationship between surface free energy and protein adsorption on metals and polymers commonly used for fabricating vascular prosthetic devices. Our results support a relationship between surface energy and protein adsorption. Albumin was more easily eluted than fibrinogen and fibronectin from most metals and all polymeric surfaces considered. Following elution, metals retained a larger fraction of protein as compared to polymers.
KW - Artificial blood vessels
KW - Blood proteins
KW - Prosthetic vascular materials
KW - Stents
KW - Surface proteins
UR - http://www.scopus.com/inward/record.url?scp=0034120229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034120229&partnerID=8YFLogxK
M3 - Article
C2 - 10947626
AN - SCOPUS:0034120229
VL - 10
SP - 127
EP - 141
JO - Journal of Long-Term Effects of Medical Implants
JF - Journal of Long-Term Effects of Medical Implants
SN - 1050-6934
IS - 1-2
ER -