Protein interactions with endovascular prosthetic surfaces

Cristina Simon; Julio C. Palmaz; Eugene A. Sprague

doi:10.1615/JLongTermEffMedImplants.v10.i12.110

Protein interactions with endovascular prosthetic surfaces

Cristina Simon, Julio C. Palmaz, Eugene A. Sprague

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Blood protein interaction with prosthetic surfaces seems to be the initial step in the chain of events leading to tissue incorporation of endovascular devices. This paper focuses on the relationship between surface free energy and protein adsorption on metals and polymers commonly used for fabricating vascular prosthetic devices. Our results support a relationship between surface energy and protein adsorption. Albumin was more easily eluted than fibrinogen and fibronectin from most metals and all polymeric surfaces considered. Following elution, metals retained a larger fraction of protein as compared to polymers.

Original language	English (US)
Pages (from-to)	127-141
Number of pages	15
Journal	Journal of Long-Term Effects of Medical Implants
Volume	10
Issue number	1-2
DOIs	https://doi.org/10.1615/JLongTermEffMedImplants.v10.i12.110
State	Published - Jan 1 2000

Keywords

Artificial blood vessels
Blood proteins
Prosthetic vascular materials
Stents
Surface proteins

ASJC Scopus subject areas

Biomedical Engineering
Dentistry(all)

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AU - Sprague, Eugene A.

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AB - Blood protein interaction with prosthetic surfaces seems to be the initial step in the chain of events leading to tissue incorporation of endovascular devices. This paper focuses on the relationship between surface free energy and protein adsorption on metals and polymers commonly used for fabricating vascular prosthetic devices. Our results support a relationship between surface energy and protein adsorption. Albumin was more easily eluted than fibrinogen and fibronectin from most metals and all polymeric surfaces considered. Following elution, metals retained a larger fraction of protein as compared to polymers.

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KW - Blood proteins

KW - Prosthetic vascular materials

KW - Stents

KW - Surface proteins

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