Protein binding of rifapentine and its 25-desacetyl metabolite in patients with pulmonary tuberculosis

Eric F. Egelund, Marc Weiner, Rajendra P. Singh, Thomas J. Prihoda, Jonathon A.L. Gelfond, Hartmut Derendorf, William R. MacKenzie, Charles A. Peloquin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly higher free rifapentine levels in African patients of black race compared to non-Africans. These data support larger pharmacokinetic/pharmacodynamic studies to confirm these findings and assess free rifapentine in relation to microbiological and clinical outcomes.

Original languageEnglish (US)
Pages (from-to)4904-4910
Number of pages7
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number8
DOIs
StatePublished - Aug 2014

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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