Protective role of melatonin in neonatal diseases

Eloisa Gitto, Lucia Marseglia, Sara Manti, Gabriella D'Angelo, Ignazio Barberi, Carmelo Salpietro, Russel J. Reiter

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Oxidative stress contributes to the severity of several newborn conditions to the extent that Saugstad coined the phrase "oxygen radical diseases of neonatology." In order to counteract free radicals damage many strategies to augment antioxidant status in ill-term and preterm infants have been proposed and several medications have been experimented with mixed results. Several studies have tested the efficacy of melatonin to counteract oxidative damage in diseases of newborns such as chronic lung disease, perinatal brain injury, necrotizing enterocolitis, and retinopathy of prematurity, giving promising results. The peculiar perinatal susceptibility to oxidative stress indicates that prophylactic use of antioxidants as melatonin could help to prevent or at least reduce oxidative stress related diseases in newborns. However, more studies are needed to confirm these beneficial effects.

Original languageEnglish (US)
Article number980374
JournalOxidative Medicine and Cellular Longevity
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Fingerprint Dive into the research topics of 'Protective role of melatonin in neonatal diseases'. Together they form a unique fingerprint.

Cite this