Protective role of ETA endothelin receptors during the acute phase of Trypanosoma cruzi infection in rats

Elizabeth R.S. Camargos, Lamara L.V. Rocha, Milene A. Rachid, Alvair P. Almeida, Anderson J. Ferreira, Antonio L. Teixeira, Egler Chiari, Matthias Barton, Mauro M. Teixeira, Conceição R.S. Machado

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Chagas' disease, caused by Trypanosoma cruzi, has an acute phase characterized by blood-circulating trypomastigotes and amastigote proliferation in several cell types, especially muscle cells. In the chronic phase, around 70% of infected people are asymptomatic (latent form). The remainder develop chagasic cardiomyopathy and/or digestive syndromes. There is evidence for aggravation of the chronic cardiac pathology by endothelin-mediated vasoconstriction. Holtzman rats have proven to be a good model for Chagas' disease acute phase and latent chronic phase. Now, we investigate the effects of prolonged treatment with an endothelin ETA receptor antagonist, BSF 461314, during the acute phase on parasitemia, coronary flow, tissue parasitism and the inflammatory process. Using isolated heart in Langendorff's preparation, endothelial dysfunction was observed only in non-treated infected animals. Histoquantitative analyses carried out in heart and diaphragm showed higher tissue parasitism and/or inflammatory process in BSF 461314-treated animals. Our data indicate that endothelin ETA receptors contribute to the initial mechanisms of parasite control. Impairment of the endothelium-dependent vasodilatation favors hazardous effects. However, blocking endothelin ET A receptors can prevent the latter.

Original languageEnglish (US)
Pages (from-to)650-656
Number of pages7
JournalMicrobes and Infection
Issue number7
StatePublished - Jun 2004
Externally publishedYes


  • Chagas' disease
  • Coronary flow
  • Endothelin
  • Inflammation
  • Parasite clearance

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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