Protection of spermatogenesis by α2u globulin in rats treated with oestrogen

Arun K. Roy, Jennie G. Byrd, Naren M. Biswas, Ajit K. Chowdhury

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

α2u GLOBULIN is an androgen-dependent rat urinary protein with a molecular weight of about 23,800 (ref. 1). In the male rat, starting from puberty until senescence, α2u globulin is synthesised and secreted by the hepatic tissue and is rapidly cleared by the kidneys into the urine2-4. In addition to its urinary concentration α2u globulin has been found to be concentrated by the salivary glands and released into the saliva (A.K.R., and J.G.B., in preparation). Synthesis of this protein could be induced in the spayed female rat by androgen, and oestrogenic compounds completely inhibited α2u synthesis in the mature male rat5. But α2u globulin does not bind testosterone, oestradiol-17β or any of their metabolites (unpublished results of A.K.R.). Pretreatment of mature male rats with oestrogen induces a dose-dependent temporary lag period within which α2u globulin is not synthesised even under androgenic stimulation. With a daily oestradiol dose of 50 μg per 100g body weight a lag period extending up to 3-4 weeks has been established6. Although the adult male rat synthesises 20-30 mg of α2u globulin per day, no physiological role of this protein has yet been established. The close parallel between the male reproductive capability and the production of α2u globulin4,5 prompted us to look into the possible reproductive role of this protein. The discovery of the oestrogen-mediated lag period in the mature male rats also provided an opportunity to look into the spermatogenic abnormalities within this lag period and any reparative effects which α2u globulin may have on such damage. The results reported here demonstrate considerable protection of spermatogenesis by α2u globulin against potential damage by oestrogen.

Original languageEnglish (US)
Pages (from-to)719-721
Number of pages3
JournalNature
Volume260
Issue number5553
DOIs
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • General

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