Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease

Agustín Anastasia, Gabriel A. De Erausquin, José Wojnacki, Daniel H. Mascó

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity.

Original languageEnglish (US)
Pages (from-to)1542-1552
Number of pages11
JournalJournal of neurochemistry
Volume103
Issue number4
DOIs
StatePublished - Nov 2007

Keywords

  • 6-hydroxydopamine
  • Electroconvulsive shock
  • Glial cell-line derived neurotrophic factor
  • Neuroprotection
  • Parkinson
  • Substantia nigra

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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