Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease

Agustín Anastasia; Gabriel A. De Erausquin; José Wojnacki; Daniel H. Mascó

doi:10.1111/j.1471-4159.2007.04856.x

Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease

Agustín Anastasia, Gabriel A. De Erausquin, José Wojnacki, Daniel H. Mascó

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity.

Original language	English (US)
Pages (from-to)	1542-1552
Number of pages	11
Journal	Journal of neurochemistry
Volume	103
Issue number	4
DOIs	https://doi.org/10.1111/j.1471-4159.2007.04856.x
State	Published - Nov 2007
Externally published	Yes

Keywords

6-hydroxydopamine
Electroconvulsive shock
Glial cell-line derived neurotrophic factor
Neuroprotection
Parkinson
Substantia nigra

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Biochemistry

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10.1111/j.1471-4159.2007.04856.x

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title = "Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease",

abstract = "Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity.",

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author = "Agust{\'i}n Anastasia and {De Erausquin}, {Gabriel A.} and Jos{\'e} Wojnacki and Masc{\'o}, {Daniel H.}",

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AU - De Erausquin, Gabriel A.

AU - Wojnacki, José

AU - Mascó, Daniel H.

PY - 2007/11

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N2 - Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity.

AB - Electroconvulsive shock (ECS) improves motor function in Parkinson's disease. In rats, ECS stimulates the expression of various factors some of which have been proposed to exert neuroprotective actions. We have investigated the effects of ECS on 6-hydroxydopamine (6-OHDA)-injected rats. Three weeks after a unilateral administration of 6-OHDA, 85-95% nigral dopaminergic neurons are lost. Chronic ECS prevented this cell loss, protect the nigrostriatal pathway (assessed by FloroGold retrograde labeling) and reduce motor impairment in 6-OHDA-treated animals. Injection of 6-OHDA caused loss of expression of glial cell-line derived neurotrophic factor (GDNF) in the substantia nigra. Chronic ECS completely prevented this loss of GDNF expression in 6-OHDA-treated animals. We also found that protected dopaminergic neurons co-express GDNF receptor proteins. These results strongly suggest that endogenous changes in GDNF expression may participate in the neuroprotective mechanism of ECS against 6-OHDA induced toxicity.

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KW - Substantia nigra

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Protection of dopaminergic neurons by electroconvulsive shock in an animal model of Parkinson's disease

Abstract

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ASJC Scopus subject areas

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