Proteasome inhibitors stimulate both bone formation and hair growth by similar mechanisms

Gregory R. Mundy, Gloria Gutierrez, Ross Garrett, Wolfgang Gallwitz, Gianni Rossini, Claus Christiansen, Andria Langenberg

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We propose that the remodeling process that occurs in localized areas on endosteal bone surfaces and in Haversian canals shares many features in common with the mammalian hair cycle. In both, there are phases of resorption or regeneration, a transition phase, and then a phase of growth, termed anagen in the hair follicle, and formation in the bone remodeling cycle. Furthermore, we suggest that these processes both use the same molecular mechanisms, and specifically the Hedgehog-BMP-Wnt signal transduction cascades.We have found that proteasome inhibitors, which enhance bone formation by effects on these cascades, also stimulate anagen induction and hair growth in the murine and human hair follicle, and propose they do so by effects on similar or identical molecular targets.

Original languageEnglish (US)
Pages (from-to)298-301
Number of pages4
JournalAnnals of the New York Academy of Sciences
Volume1117
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Anagen
  • Bone formation
  • Bone morphogenetic protein
  • Hair follicle
  • Proteasome inhibitors

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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