Prostate-specific membrane antigen is produced in tumor-associated neovasculature

Sam S. Chang, Denise S. O'Keefe, Dean J. Bacich, Victor E. Reuter, Warren D.W. Heston, Paul B. Gaudin

Research output: Contribution to journalArticle

338 Scopus citations

Abstract

Prostate-specific membrane antigen (PSMA), a type II transmembrane protein, was originally thought to be strictly expressed in prostatic tissue, but recent studies have demonstrated PSMA protein expression in nonprostatic tumor neovasculature as well. Using immunohistochemistry, reverse transcription-PCR assays, and in situ hybridization, we have demonstrated PSMA mRNA transcripts and protein expression in the endothelium of tumor- associated neovasculature of multiple nonprostatic solid malignancies. In addition, we found no PSMA mRNA or protein expression in the vascular endothelial cells of corresponding benign tissue examples. Our findings expand the possible therapeutic role of PSMA and establish it as a unique biomarker specifically produced and expressed by tumor-associated neovasculature but not produced or expressed by normal vessels.

Original languageEnglish (US)
Pages (from-to)2674-2681
Number of pages8
JournalClinical Cancer Research
Volume5
Issue number10
StatePublished - Oct 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Chang, S. S., O'Keefe, D. S., Bacich, D. J., Reuter, V. E., Heston, W. D. W., & Gaudin, P. B. (1999). Prostate-specific membrane antigen is produced in tumor-associated neovasculature. Clinical Cancer Research, 5(10), 2674-2681.