TY - JOUR
T1 - Prostate cancer prevention
T2 - What do we know now, and when will we know more?
AU - Thompson, Ian M.
AU - Basler, Joseph
AU - Hensley, Deborah
AU - Von Merveldt, Dendra
AU - Jenkins, Carol A.
AU - Higgins, Betsy
AU - Leach, Robin
AU - Troyer, Dean
AU - Pollock, Brad
PY - 2003/3
Y1 - 2003/3
N2 - Prostate cancer prevention is now one of the most aggressively investigated areas of urologic oncology, with > 30,000 men currently participating in clinical trials in the United States alone. The Prostate Cancer Prevention Trial will complete end-of-study prostate biopsies in May 2004, and the Selenium and Vitamin E Cancer Prevention Trial is rapidly reaching its accrual goal 1-2 years ahead of schedule. These 2 studies will give definitive answers regarding 3 of the most important potential preventive interventions: finasteride, vitamin E, and selenium. Many phase II and biomarker-modulation studies are also ongoing, testing a host of other interventions. It is hoped that, within a short period of time, the clinician will be provided with strategies to reduce the risk of the disease.
AB - Prostate cancer prevention is now one of the most aggressively investigated areas of urologic oncology, with > 30,000 men currently participating in clinical trials in the United States alone. The Prostate Cancer Prevention Trial will complete end-of-study prostate biopsies in May 2004, and the Selenium and Vitamin E Cancer Prevention Trial is rapidly reaching its accrual goal 1-2 years ahead of schedule. These 2 studies will give definitive answers regarding 3 of the most important potential preventive interventions: finasteride, vitamin E, and selenium. Many phase II and biomarker-modulation studies are also ongoing, testing a host of other interventions. It is hoped that, within a short period of time, the clinician will be provided with strategies to reduce the risk of the disease.
KW - Biomarker
KW - Early detection
KW - Hormonal agents
KW - Selenium
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=0041970199&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041970199&partnerID=8YFLogxK
U2 - 10.3816/CGC.2003.n.002
DO - 10.3816/CGC.2003.n.002
M3 - Review article
C2 - 15040879
AN - SCOPUS:0041970199
VL - 1
SP - 215
EP - 220
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
SN - 1558-7673
IS - 4
ER -