Prostate cancer incidence and survival in immigrants to Sweden

Kari Hemminki, Donna P Ankerst, Jan Sundquist, Seyed Mohsen Mousavi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The large international variation in the incidence of prostate cancer (PC) is well known but the underlying reasons are not understood. We want to compare PC incidence and survival among immigrants to Sweden in order to explain the international differences. Methods: Cancer data were obtained from the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for PC in first-degree immigrants by country of birth. The immigrants were classified into four groups by SIR and area of origin. Survival in PC was assessed by hazard ratio (HR) in the four groups. In some analyses, clinical stage of PC was assessed by the tumor, node, and metastasis classification. Results: The SIR was 0.47 (95 % confidence interval 0.43-0.51) for immigrants with the lowest risk, constituting men from Turkey, Middle East, Asia, and Chile. The HR was 0.60 (0.45-0.81) for these men and it was 0.49 if they had stayed 20+ years in Sweden. The SIR in screening detected PC, T1c, was 0.55. Among these men, screening detected PC constituted 34.5 % of all PC, compared to 29.0 % among Swedes (p = 0.10). Conclusions: The results showed that the non-European immigrants, of mainly Middle East, Asian, and Chilean origin, with the lowest risk of PC, also had the most favorable survival in PC. As the available clinical features of PC at diagnosis or the distribution of known risk factors could not explain the differences, a likely biological mechanism through a favorable androgenic hormonal host environment is suggested as an explanation of the observed effects.

Original languageEnglish (US)
Pages (from-to)1483-1488
Number of pages6
JournalWorld Journal of Urology
Volume31
Issue number6
DOIs
StatePublished - Dec 2013

Fingerprint

Sweden
Prostatic Neoplasms
Survival
Incidence
Middle East
Neoplasms
Far East
Chile
Turkey
Registries
Parturition
Confidence Intervals
Neoplasm Metastasis

Keywords

  • Immigrant
  • Incidence
  • Screening TNM
  • Survival

ASJC Scopus subject areas

  • Urology

Cite this

Hemminki, K., Ankerst, D. P., Sundquist, J., & Mousavi, S. M. (2013). Prostate cancer incidence and survival in immigrants to Sweden. World Journal of Urology, 31(6), 1483-1488. https://doi.org/10.1007/s00345-012-1021-z

Prostate cancer incidence and survival in immigrants to Sweden. / Hemminki, Kari; Ankerst, Donna P; Sundquist, Jan; Mousavi, Seyed Mohsen.

In: World Journal of Urology, Vol. 31, No. 6, 12.2013, p. 1483-1488.

Research output: Contribution to journalArticle

Hemminki, K, Ankerst, DP, Sundquist, J & Mousavi, SM 2013, 'Prostate cancer incidence and survival in immigrants to Sweden', World Journal of Urology, vol. 31, no. 6, pp. 1483-1488. https://doi.org/10.1007/s00345-012-1021-z
Hemminki, Kari ; Ankerst, Donna P ; Sundquist, Jan ; Mousavi, Seyed Mohsen. / Prostate cancer incidence and survival in immigrants to Sweden. In: World Journal of Urology. 2013 ; Vol. 31, No. 6. pp. 1483-1488.
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