TY - JOUR
T1 - Prostate cancer chemoprevention agent development
T2 - The National Cancer Institute, Division of Cancer Prevention portfolio
AU - Parnes, Howard L.
AU - House, Margaret G.
AU - Kagan, Jacob
AU - Kausal, David J.
AU - Lieberman, Ronald
AU - Fleshner, Neil
AU - Thompson, Ian M.
AU - Djavan, Bob
PY - 2004/2
Y1 - 2004/2
N2 - Purpose: We describe the current National Cancer Institute chemoprevention agent development program and provide a summary of the intermediate end points used. Materials and Methods: The National Cancer Institute is currently sponsoring a wide range of studies of promising chemoprevention agents in a variety of informative cohorts, eg high grade prostatic intraepithelial neoplasia, positive family history of cancer, increased prostate specific antigen with negative biopsies, prostate cancer followed expectantly, prostate cancer awaiting definitive therapy and the general population. The rationale for each agent under investigation is derived from epidemiological observations, prostate cancer treatment trials, secondary analyses of large cancer prevention studies, an understanding of cancer biology and prostate carcinogenesis, and/or experimental animal models. Results: Carcinogenesis is a multistep process occurring over decades which is characterized by disruption of the normal regulatory pathways controlling cellular proliferation, programmed cell death and differentiation. Administration of agents to reverse, inhibit or slow this process of malignant transformation is known as chemoprevention. Conclusion: Chemoprevention represents a promising approach to reducing the morbidity and mortality of prostate cancer. A variety of agents are currently being studied in phase 2 clinical trials, some of which may warrant subsequent evaluation in phase 3 trials with definitive cancer end points. Two large phase 3 trials, the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial, which are ongoing, are also sponsored by the National Cancer Institute.
AB - Purpose: We describe the current National Cancer Institute chemoprevention agent development program and provide a summary of the intermediate end points used. Materials and Methods: The National Cancer Institute is currently sponsoring a wide range of studies of promising chemoprevention agents in a variety of informative cohorts, eg high grade prostatic intraepithelial neoplasia, positive family history of cancer, increased prostate specific antigen with negative biopsies, prostate cancer followed expectantly, prostate cancer awaiting definitive therapy and the general population. The rationale for each agent under investigation is derived from epidemiological observations, prostate cancer treatment trials, secondary analyses of large cancer prevention studies, an understanding of cancer biology and prostate carcinogenesis, and/or experimental animal models. Results: Carcinogenesis is a multistep process occurring over decades which is characterized by disruption of the normal regulatory pathways controlling cellular proliferation, programmed cell death and differentiation. Administration of agents to reverse, inhibit or slow this process of malignant transformation is known as chemoprevention. Conclusion: Chemoprevention represents a promising approach to reducing the morbidity and mortality of prostate cancer. A variety of agents are currently being studied in phase 2 clinical trials, some of which may warrant subsequent evaluation in phase 3 trials with definitive cancer end points. Two large phase 3 trials, the Prostate Cancer Prevention Trial and the Selenium and Vitamin E Cancer Prevention Trial, which are ongoing, are also sponsored by the National Cancer Institute.
KW - Clinical trials
KW - Prevention
KW - Prostatic neoplasms
UR - http://www.scopus.com/inward/record.url?scp=0347759905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347759905&partnerID=8YFLogxK
U2 - 10.1097/01.ju.0000107220.64675.74
DO - 10.1097/01.ju.0000107220.64675.74
M3 - Article
C2 - 14713758
AN - SCOPUS:0347759905
VL - 171
SP - S68-S75
JO - Investigative Urology
JF - Investigative Urology
SN - 0022-5347
IS - 2 II
ER -