Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells

J. I. Kreisberg, M. J. Karnovsky, L. Levine

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Prostaglandin production was measured in homogeneous cultures that had been characterized as glomerular epithelial and mesangial cells. Glomerular epithelial cells produced ten times more cyclooxygenase products than mesangial cells; 88 to 95% of its products were prostacyclin. Mesangial cells produced predominantly prostaglandin E2 (57 to 66%); only 14 to 15% of the prostaglandins produced by mesangial cells was PGI2. Cultured glomerular epithelial and mesangial cells produced little prostaglandin D2, thromboxane, 12-L-hydroxyeicosatetraenoic acid, or 6-sulfido-peptide-containing leukotrienes

Original languageEnglish (US)
Pages (from-to)355-359
Number of pages5
JournalKidney international
Volume22
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

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