Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells

J. I. Kreisberg; M. J. Karnovsky; L. Levine

doi:10.1038/ki.1982.181

Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells

J. I. Kreisberg, M. J. Karnovsky, L. Levine

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30 Scopus citations

Abstract

Prostaglandin production was measured in homogeneous cultures that had been characterized as glomerular epithelial and mesangial cells. Glomerular epithelial cells produced ten times more cyclooxygenase products than mesangial cells; 88 to 95% of its products were prostacyclin. Mesangial cells produced predominantly prostaglandin E₂ (57 to 66%); only 14 to 15% of the prostaglandins produced by mesangial cells was PGI₂. Cultured glomerular epithelial and mesangial cells produced little prostaglandin D₂, thromboxane, 12-L-hydroxyeicosatetraenoic acid, or 6-sulfido-peptide-containing leukotrienes

Original language	English (US)
Pages (from-to)	355-359
Number of pages	5
Journal	Kidney international
Volume	22
Issue number	4
DOIs	https://doi.org/10.1038/ki.1982.181
State	Published - 1982
Externally published	Yes

ASJC Scopus subject areas

Nephrology

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10.1038/ki.1982.181

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abstract = "Prostaglandin production was measured in homogeneous cultures that had been characterized as glomerular epithelial and mesangial cells. Glomerular epithelial cells produced ten times more cyclooxygenase products than mesangial cells; 88 to 95% of its products were prostacyclin. Mesangial cells produced predominantly prostaglandin E2 (57 to 66%); only 14 to 15% of the prostaglandins produced by mesangial cells was PGI2. Cultured glomerular epithelial and mesangial cells produced little prostaglandin D2, thromboxane, 12-L-hydroxyeicosatetraenoic acid, or 6-sulfido-peptide-containing leukotrienes",

author = "Kreisberg, {J. I.} and Karnovsky, {M. J.} and L. Levine",

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AU - Karnovsky, M. J.

AU - Levine, L.

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Prostaglandin production by homogeneous cultures of rat glomerular epithelial and mesangial cells

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