Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer; Greta L. Gleason; Leroy G. Hardin; Jeffrey S. Bohrman; Thomas J. Slaga

doi:10.1093/carcin/1.3.245

Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer, Greta L. Gleason, Leroy G. Hardin, Jeffrey S. Bohrman, Thomas J. Slaga

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF_2α enhances promotion, whereas PGE₁ consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE₂ enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Carcinogenesis
Volume	1
Issue number	3
DOIs	https://doi.org/10.1093/carcin/1.3.245
State	Published - Mar 1980
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

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title = "Prostaglandin modulation of phorbol ester skin tumor promotion",

abstract = "TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.",

author = "Susan M.fischer and Gleason, {Greta L.} and Hardin, {Leroy G.} and Bohrman, {Jeffrey S.} and Slaga, {Thomas J.}",

note = "Funding Information: Research sponsored jointly by the National Cancer Institute under Interagency Agreement Y01-CP-70227 and the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation. Jeffrey S.Bohrmann is a Postdoctoral Investigator supported by Carcinogenesis Training Grant CA 05296 from the National Cancer Institute",

year = "1980",

month = mar,

doi = "10.1093/carcin/1.3.245",

language = "English (US)",

volume = "1",

pages = "245--248",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

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T1 - Prostaglandin modulation of phorbol ester skin tumor promotion

AU - M.fischer, Susan

AU - Gleason, Greta L.

AU - Hardin, Leroy G.

AU - Bohrman, Jeffrey S.

AU - Slaga, Thomas J.

N1 - Funding Information: Research sponsored jointly by the National Cancer Institute under Interagency Agreement Y01-CP-70227 and the Office of Health and Environmental Research, U.S. Department of Energy, under contract W-7405-eng-26 with the Union Carbide Corporation. Jeffrey S.Bohrmann is a Postdoctoral Investigator supported by Carcinogenesis Training Grant CA 05296 from the National Cancer Institute

PY - 1980/3

Y1 - 1980/3

N2 - TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

AB - TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

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JO - Carcinogenesis

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Prostaglandin modulation of phorbol ester skin tumor promotion

Abstract

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