Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer; Greta L. Gleason; Leroy G. Hardin; Jeffrey S. Bohrman; Thomas J. Slaga

doi:10.1093/carcin/1.3.245

Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer, Greta L. Gleason, Leroy G. Hardin, Jeffrey S. Bohrman, Thomas J. Slaga

Pharmacology

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF_2α enhances promotion, whereas PGE₁ consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE₂ enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Carcinogenesis
Volume	1
Issue number	3
DOIs	https://doi.org/10.1093/carcin/1.3.245
State	Published - Mar 1 1980

Fingerprint

ASJC Scopus subject areas

Cancer Research

Cite this

M.fischer, S., Gleason, G. L., Hardin, L. G., Bohrman, J. S., & Slaga, T. J. (1980). Prostaglandin modulation of phorbol ester skin tumor promotion. Carcinogenesis, 1(3), 245-248. https://doi.org/10.1093/carcin/1.3.245

@article{8b5e770382df4b5ea1311ca9a4154985,

title = "Prostaglandin modulation of phorbol ester skin tumor promotion",

abstract = "TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.",

author = "Susan M.fischer and Gleason, {Greta L.} and Hardin, {Leroy G.} and Bohrman, {Jeffrey S.} and Slaga, {Thomas J.}",

year = "1980",

month = mar

day = "1",

doi = "10.1093/carcin/1.3.245",

language = "English (US)",

volume = "1",

pages = "245--248",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Prostaglandin modulation of phorbol ester skin tumor promotion

AU - M.fischer, Susan

AU - Gleason, Greta L.

AU - Hardin, Leroy G.

AU - Bohrman, Jeffrey S.

AU - Slaga, Thomas J.

PY - 1980/3/1

Y1 - 1980/3/1

N2 - TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

AB - TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

UR - http://www.scopus.com/inward/record.url?scp=0019205154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019205154&partnerID=8YFLogxK

U2 - 10.1093/carcin/1.3.245

DO - 10.1093/carcin/1.3.245

M3 - Article

C2 - 22283005

AN - SCOPUS:0019205154

VL - 1

SP - 245

EP - 248

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 3

ER -

Access to Document

10.1093/carcin/1.3.245