Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer; Greta L. Gleason; Leroy G. Hardin; Jeffrey S. Bohrman; Thomas J. Slaga

doi:10.1093/carcin/1.3.245

Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer, Greta L. Gleason, Leroy G. Hardin, Jeffrey S. Bohrman, Thomas J. Slaga

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF_2α enhances promotion, whereas PGE₁ consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE₂ enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

Original language	English (US)
Pages (from-to)	245-248
Number of pages	4
Journal	Carcinogenesis
Volume	1
Issue number	3
DOIs	https://doi.org/10.1093/carcin/1.3.245
State	Published - Mar 1 1980
Externally published	Yes

ASJC Scopus subject areas

Cancer Research

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abstract = "TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.",

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AU - Bohrman, Jeffrey S.

AU - Slaga, Thomas J.

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