Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer, Greta L. Gleason, Leroy G. Hardin, Jeffrey S. Bohrman, Thomas J. Slaga

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Abstract

TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalCarcinogenesis
Volume1
Issue number3
DOIs
StatePublished - Mar 1 1980

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ASJC Scopus subject areas

  • Cancer Research

Cite this

M.fischer, S., Gleason, G. L., Hardin, L. G., Bohrman, J. S., & Slaga, T. J. (1980). Prostaglandin modulation of phorbol ester skin tumor promotion. Carcinogenesis, 1(3), 245-248. https://doi.org/10.1093/carcin/1.3.245