Prostaglandin modulation of phorbol ester skin tumor promotion

Susan M.fischer, Greta L. Gleason, Leroy G. Hardin, Jeffrey S. Bohrman, Thomas J. Slaga

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalCarcinogenesis
Volume1
Issue number3
DOIs
StatePublished - Mar 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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