Abstract
TPA promotion of skin tumors in mice can be modified by application of various prostaglandins or their precursors. The effects depend on the particular prostaglandin used: PGF2α enhances promotion, whereas PGE1 consistently inhibits promotion. Time of application of the prostaglandin with respect to TPA determines whether PGE2 enhances or inhibits. Dose-dependent inhibition was observed for arachidonic acid. The prostaglandins alone were unable to elicit tumors in initiated mice.
Original language | English (US) |
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Pages (from-to) | 245-248 |
Number of pages | 4 |
Journal | Carcinogenesis |
Volume | 1 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research