Prostacyclin selectively enhances blood flow in areas of the GI tract prone to stress ulceration

Harold V. Gaskill, Kenneth R. Sirinek, Barry A. Levine

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

This study assessed the effect of continuous infusion of prostacyclin on tissue blood flow throughout the GI tract to see whether small and large bowel flow was also affected. Twelve miniature swine were anesthetized, ventilated, and hemodynamically monitored. After stabilization each animal received either prostacyclin in buffer at 0.1 mcg/kg/minute for 3 hours or buffer alone (controls). Tissue blood flow was documented at baseline and at 1, 2, and 3 hours of prostacyclin infusion by injection of radiolabeled spheres. Prostacyclin infusion did not significantly affect mean arterial pressure, heart rate, or cardiac index compared to controls. At 3 hours tissue blood flow was significantly increased in the gastric mucosa (f 225%), small bowel (f 110%), cecum (j 260%), and transverse colon (j 160%) compared to controls. Prostacyclin may be an effective agent for prevention of ischemia in all areas of the GI tract prone to stress ulceration.

Original languageEnglish (US)
Pages (from-to)397-402
Number of pages6
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume24
Issue number5
DOIs
StatePublished - May 1984

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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