Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient

B. A. Levine, P. A. Petroff, C. L. Slade, Basil A Pruitt

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

The addition of an inhalation injury to a cutaneous burn results in a significant increase in patient mortality rates, both from early pulmonary edema and, later, Gram-negative pneumonitis. Steroids have been shown to decrease mortality in an inhalation injury model. Aerosolization of gentamicin has been used successfully to treat severe bronchial infections. Therefore, a prospective, randomized trial was undertaken to evaluate both these drugs. Sixty burned patients, with inhalation injury confirmed by bronchoscopy and 133Xenon scan, were studied: 30 patients received either dexamethasone or saline placebo for 3 days; serial pulmonary functions were measured on those able to cooperate; another 30 patients received either aerosolized gentamicin or placebo for 10 days. Both drug-treated groups were comparable to their controls in age and mean burn size. Results of the steroid trial showed no major differences in mortality, pulmonary complications, or changes in pulmonary functions. Results of the gentamicin trial showed no major differences in mortality, time of death, or pulmonary and septic complications between treated and control groups.

Original languageEnglish (US)
Pages (from-to)188-193
Number of pages6
JournalJournal of Trauma
Volume18
Issue number3
StatePublished - 1978
Externally publishedYes

Fingerprint

Gentamicins
Inhalation
Dexamethasone
Lung
Mortality
Wounds and Injuries
Steroids
Placebos
Bronchoscopy
Pulmonary Edema
Therapeutics
Pharmaceutical Preparations
Pneumonia
Control Groups
Skin
Infection

ASJC Scopus subject areas

  • Surgery

Cite this

Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient. / Levine, B. A.; Petroff, P. A.; Slade, C. L.; Pruitt, Basil A.

In: Journal of Trauma, Vol. 18, No. 3, 1978, p. 188-193.

Research output: Contribution to journalArticle

Levine, B. A. ; Petroff, P. A. ; Slade, C. L. ; Pruitt, Basil A. / Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient. In: Journal of Trauma. 1978 ; Vol. 18, No. 3. pp. 188-193.
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