Prospective randomized trial of ligasure versus harmonic hemostasis technique in thyroidectomy

Reza Rahbari, Aarti Mathur, Mio Kitano, Marlon Guerrero, Wen T. Shen, Quan Yang Duh, Orlo H. Clark, Electron Kebebew

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: Two surgical devices have become popular in thyroid surgery: a bipolar energy sealing system (B) and ultrasonic coagulation (UC). Retrospective and prospective studies have demonstrated that the use of these surgical devices for thyroidectomy compared with conventional thyroidectomy (clamp-and-tie) techniques reduces operative time and cost. We conducted a prospective randomized clinical trial to determine if there is any difference in operative time and cost between B and UC. Materials and Methods: A single-blinded prospective randomized controlled trial was conducted at a tertiary referral center. A total of 90 patients who required a thyroidectomy for thyroid cancer, thyroid nodules, or hyperthyroidism were randomized to either B or UC during thyroidectomy. The operative time and cost of thyroidectomy were compared between the two groups. Results: There was no statistically significant difference in patient age, gender, body mass index, indication for thyroidectomy and thyroid gland weight between the two groups. There was no statistically significant difference in operating room cost or total cost for thyroidectomy between the B and UC groups. There was also no statistically significant difference in the operative time between the B and UC groups (187.6 vs. 184.2 min, P = 0.48) or in postoperative complication rates. The only statistically significant difference in total cost was between surgeons independent of the device used (P<0.01). Conclusions: In thyroid surgery, total cost and operative time were similar between the two surgical devices used.

Original languageEnglish (US)
Pages (from-to)1023-1027
Number of pages5
JournalAnnals of Surgical Oncology
Issue number4
StatePublished - Apr 2011
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Surgery


Dive into the research topics of 'Prospective randomized trial of ligasure versus harmonic hemostasis technique in thyroidectomy'. Together they form a unique fingerprint.

Cite this