Prospective observational trial of low-dose skin electron beam therapy in mycosis fungoides using a rotational technique

Neil B. Newman, Chirayu G. Patel, George X. Ding, John A. Zic, Jeffrey Zwerner, Evan C. Osmundson, Austin N. Kirschner

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Introduction: Low-dose total skin electron beam therapy provides a durable treatment response for skin lesions caused by cutaneous T-cell lymphoma. We prospectively assessed the durability of response and quality of life for patients receiving low-dose total skin electron beam therapy using a novel rotational technique and dosing regimen. Methods: Patients completed baseline Skindex-29 quality-of-life surveys and had baseline Modified Severity-Weighted Assessment Tool score recorded. Patients received 12 Gy in 12 fractions with a dual-field rotational technique. The primary outcome was overall response rate, with the secondary outcomes being time to treatment response, duration of clinical benefit, and quality-of-life change. Results: We enrolled 20 patients and recorded an overall response rate of 90%. The median time to treatment response was 6.5 weeks. The baseline Modified Severity-Weighted Assessment Tool score was 55.6 and it declined to a median of 2.2 at last follow-up (P <.001). The median duration of clinical benefit was 21 months. There was a decline in the Skindex-29 total score and every subdomain when each follow-up visit was compared (P =.004). Conclusions: This prospective study demonstrated a very high overall response rate and improvement in skin-related quality of life. Low-dose rotational total skin electron beam therapy can be implemented routinely in clinical practice.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume85
Issue number1
DOIs
StatePublished - Jul 2021
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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