Propofol for benzodiazepine-refractory alcohol withdrawal in a non-mechanically ventilated patient

Darrel W. Hughes, Elizabeth Vanwert, Lauren Lepori, Bruce D. Adams

Research output: Contribution to journalArticle

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Abstract

Long-term alcohol use confers neurochemical changes in response to alcohol's exogenous inhibitory effects. Downregulation and decreased sensitivity of ã-aminobutyric acid receptors render benzodiazepines less effective at controlling psychomotor agitation. Propofol has been reported to have successfully relieved alcohol withdrawal syndrome (AWS) symptoms in part because of activation of γ-aminobutyric acid channels in combination with antagonism of excitatory amino acids such as N-methyl-D-aspartate. Successful use of propofol in refractory AWS in patients with endotracheal intubation and mechanical ventilation has been reported. We present a case of resolution of AWS symptoms in a benzodiazepine-refractory, nonintubated, non-mechanically ventilated alcohol withdrawal patient with low-dose, continuous-infusion propofol.

Original languageEnglish (US)
Pages (from-to)112.e3-112.e4
JournalAmerican Journal of Emergency Medicine
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2014

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ASJC Scopus subject areas

  • Emergency Medicine

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