Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection

Teclegiorgis Gebremariam; Sondus Alkhazraji; Lin Lin; Nathan P. Wiederhold; Edward P. Garvey; William J. Hoekstra; Robert J. Schotzinger; Thomas F. Patterson; Scott G. Filler; Ashraf S. Ibrahim

doi:10.1128/AAC.00390-17

Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection

Teclegiorgis Gebremariam, Sondus Alkhazraji, Lin Lin, Nathan P. Wiederhold, Edward P. Garvey, William J. Hoekstra, Robert J. Schotzinger, Thomas F. Patterson, Scott G. Filler, Ashraf S. Ibrahim

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20 Scopus citations

Abstract

We compared prophylactic or continuous therapy with the investiga-tional drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus. In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.

Original language	English (US)
Article number	e00390-17
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00390-17
State	Published - Sep 2017

Keywords

Mucormycosis
Murine
Prophylaxis
Rhizopus arrhizus
VT-1161

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00390-17

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Gebremariam, T., Alkhazraji, S., Lin, L., Wiederhold, N. P., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Patterson, T. F., Filler, S. G., & Ibrahim, A. S. (2017). Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection. Antimicrobial agents and chemotherapy, 61(9), [e00390-17]. https://doi.org/10.1128/AAC.00390-17

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title = "Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection",

abstract = "We compared prophylactic or continuous therapy with the investiga-tional drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus. In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.",

keywords = "Mucormycosis, Murine, Prophylaxis, Rhizopus arrhizus, VT-1161",

author = "Teclegiorgis Gebremariam and Sondus Alkhazraji and Lin Lin and Wiederhold, {Nathan P.} and Garvey, {Edward P.} and Hoekstra, {William J.} and Schotzinger, {Robert J.} and Patterson, {Thomas F.} and Filler, {Scott G.} and Ibrahim, {Ashraf S.}",

note = "Funding Information: This work was supported by Public Health Service contract HHSN272201000038I (NIH task orders A13 and 93) and grant R01 AI063503. We thank Clara Baldin, Abdullah Alqarihi, and Lina Zhang for their technical assistance. Publisher Copyright: Copyright {\textcopyright} 2017 American Society for Microbiology. All Rights Reserved.",

year = "2017",

month = sep,

doi = "10.1128/AAC.00390-17",

language = "English (US)",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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AU - Gebremariam, Teclegiorgis

AU - Alkhazraji, Sondus

AU - Lin, Lin

AU - Wiederhold, Nathan P.

AU - Garvey, Edward P.

AU - Hoekstra, William J.

AU - Schotzinger, Robert J.

AU - Patterson, Thomas F.

AU - Filler, Scott G.

AU - Ibrahim, Ashraf S.

N1 - Funding Information: This work was supported by Public Health Service contract HHSN272201000038I (NIH task orders A13 and 93) and grant R01 AI063503. We thank Clara Baldin, Abdullah Alqarihi, and Lina Zhang for their technical assistance. Publisher Copyright: Copyright © 2017 American Society for Microbiology. All Rights Reserved.

PY - 2017/9

Y1 - 2017/9

N2 - We compared prophylactic or continuous therapy with the investiga-tional drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus. In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.

AB - We compared prophylactic or continuous therapy with the investiga-tional drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus. In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.

KW - Mucormycosis

KW - Murine

KW - Prophylaxis

KW - Rhizopus arrhizus

KW - VT-1161

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Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection

Abstract

Keywords

ASJC Scopus subject areas

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