Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

Junwei Zeng; Rongjuan Mi; Yingchun Wang; Yujing Li; Li Lin; Bing Yao; Lina Song; Irma Van Die; Arlene B. Chapman; Richard D. Cummings; Peng Jin; Tongzhong Ju

doi:10.1074/jbc.M115.654244

Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

Junwei Zeng
, Rongjuan Mi
, Yingchun Wang
, Yujing Li
, Li Lin
, Bing Yao
, Lina Song
, Irma Van Die
, Arlene B. Chapman
, Richard D. Cummings
, Peng Jin
, Tongzhong Ju

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

Original language	English (US)
Pages (from-to)	19018-19033
Number of pages	16
Journal	Journal of Biological Chemistry
Volume	290
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M115.654244
State	Published - Jul 31 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.654244

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title = "Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation",

abstract = "Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.",

author = "Junwei Zeng and Rongjuan Mi and Yingchun Wang and Yujing Li and Li Lin and Bing Yao and Lina Song and \{Van Die\}, Irma and Chapman, \{Arlene B.\} and Cummings, \{Richard D.\} and Peng Jin and Tongzhong Ju",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

day = "31",

doi = "10.1074/jbc.M115.654244",

language = "English (US)",

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TY - JOUR

T1 - Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

AU - Zeng, Junwei

AU - Mi, Rongjuan

AU - Wang, Yingchun

AU - Li, Yujing

AU - Lin, Li

AU - Yao, Bing

AU - Song, Lina

AU - Van Die, Irma

AU - Chapman, Arlene B.

AU - Cummings, Richard D.

AU - Jin, Peng

AU - Ju, Tongzhong

PY - 2015/7/31

Y1 - 2015/7/31

N2 - Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

AB - Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

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DO - 10.1074/jbc.M115.654244

M3 - Article

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AN - SCOPUS:84940509883

SN - 0021-9258

VL - 290

SP - 19018

EP - 19033

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

Abstract

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