Abstract
Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.
Original language | English (US) |
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Pages (from-to) | 19018-19033 |
Number of pages | 16 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 31 |
DOIs | |
State | Published - Jul 31 2015 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Cell Biology