Promoters of human cosmc and T-synthase genes are similar in structure, yet different in epigenetic regulation

Junwei Zeng, Rongjuan Mi, Yingchun Wang, Yujing Li, Li Lin, Bing Yao, Lina Song, Irma Van Die, Arlene B. Chapman, Richard D. Cummings, Peng Jin, Tongzhong Ju

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Transcriptional regulation of human T-synthase and Cosmc is unknown. Results: Minimal promoters for Cosmc and T-synthase are located in CpG islands, and the promoter of Cosmc, but not T-synthase, was hypermethylated in Tn4 B cells. Conclusion: Promoters of Cosmc and T-synthase are similarly structured, yet different in epigenetic regulation. Significance: These data aid in understanding the role of these genes in biology and diseases.

Original languageEnglish (US)
Pages (from-to)19018-19033
Number of pages16
JournalJournal of Biological Chemistry
Volume290
Issue number31
DOIs
StatePublished - Jul 31 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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