Promoter prediction based on a multiple instance learning scheme

Xuefeng Zhou, Jianhua Ruan, Weixiong Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Core promoters are crucial regions for initiation of gene transcription. Identification of core promoters is important to the understanding of transcriptional regulation and elucidation of relationships among genes of an organism. Experimentally locating core promoters is laborious and costly. Therefore, it is desirable to develop computational approaches to support and complement experimental methods. However, computational prediction of core promoters of eukaryotic species is challenging. In this paper, we first formulate the core promoter prediction problem as a variation of the multiple instance learning problem. We then develop a new algorithm for identifying core promoters with a high positive prediction rate and a high sensitivity. Since many computational biology problems can be formulated under the multiple instance learning paradigm, our approach may inspire future research of applying multiple instance learning techniques to complex biology problems and our method may have broad potential applications.

Original languageEnglish (US)
Title of host publication2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Pages295-301
Number of pages7
DOIs
StatePublished - Oct 25 2010
Externally publishedYes
Event2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010 - Niagara Falls, NY, United States
Duration: Aug 2 2010Aug 4 2010

Publication series

Name2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010

Other

Other2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
CountryUnited States
CityNiagara Falls, NY
Period8/2/108/4/10

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Information Management

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  • Cite this

    Zhou, X., Ruan, J., & Zhang, W. (2010). Promoter prediction based on a multiple instance learning scheme. In 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010 (pp. 295-301). (2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010). https://doi.org/10.1145/1854776.1854817