Abstract
Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1422-1425 |
| Number of pages | 4 |
| Journal | Neural Regeneration Research |
| Volume | 12 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2017 |
| Externally published | Yes |
Keywords
- Disease modifying therapy
- Huntington’s disease
- Inflammation
- Treatment
ASJC Scopus subject areas
- Neuroscience (miscellaneous)
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