TY - JOUR
T1 - Promises and pitfalls of immune-based strategies for huntington’s disease
AU - Colpo, Gabriela Delevati
AU - Stimming, Erin Furr
AU - Rocha, Natalia Pessoa
AU - Teixeira, Antonio Lucio
N1 - Publisher Copyright:
© 2017, Medknow Publications. All rights reserved.
PY - 2017/9
Y1 - 2017/9
N2 - Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.
AB - Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.
KW - Disease modifying therapy
KW - Huntington’s disease
KW - Inflammation
KW - Treatment
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U2 - 10.4103/1673-5374.215245
DO - 10.4103/1673-5374.215245
M3 - Review article
AN - SCOPUS:85032435219
SN - 1673-5374
VL - 12
SP - 1422
EP - 1425
JO - Neural Regeneration Research
JF - Neural Regeneration Research
IS - 9
ER -