Promises and pitfalls of immune-based strategies for huntington’s disease

Gabriela Delevati Colpo, Erin Furr Stimming, Natalia Pessoa Rocha, Antonio Lucio Teixeira

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin. Several studies have suggested that inflammation is an important feature of HD and it is already observed in the early stages of the disease. Recently, new molecules presenting anti-inflammatory and/or immunomodulatory have been investigated for HD. The objective of this review is to discuss the data obtained so far on the immune-based therapeutic strategies for HD.

Original languageEnglish (US)
Pages (from-to)1422-1425
Number of pages4
JournalNeural Regeneration Research
Volume12
Issue number9
DOIs
StatePublished - Sep 2017
Externally publishedYes

Keywords

  • Disease modifying therapy
  • Huntington’s disease
  • Inflammation
  • Treatment

ASJC Scopus subject areas

  • Developmental Neuroscience

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