Prolonged mechanical support in children with severe adenoviral infections: A case series and review of the literature

Punkaj Gupta, Joseph D. Tobias, Sunali Goyal, Peter Hervie, Jason B. Harris, Efraim Sadot, Natan Noviski

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Adenovirus infections occur primarily in infants and children less than 5 years of age, accounting for 2% to 5% of respiratory illnesses in the pediatric population and 4% to 10% of childhood pneumonias. Although the majority of children with adenovirus disease develop mild upper respiratory tract disease, more severe disease may occur with involvement of the lower respiratory tract characterized by pneumonitis and/or small airways disease. The authors present a case series of 3 high-risk children with severe lower respiratory tract adenoviral infections. These cases demonstrate the potential for the development of severe respiratory involvement from adenovirus in infants and children with comorbid conditions and illustrate that there may be a rapid progression of the disease as well as the need, in selected circumstances, for prolonged mechanical support. We review the role of adenovirus in lower respiratory tract infections in infants and children, its potential to result in life-threatening complications in pediatric patients with comorbid conditions, and the potential life-saving role of mechanical ventilation and extracorporeal life support (ECLS) in these children.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalJournal of Intensive Care Medicine
Issue number4
StatePublished - Jul 2011
Externally publishedYes


  • Adenovirus
  • bronchiolitis obliterans
  • extracorporeal life support
  • mechanical ventilation
  • respiratory failure

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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