Prolonged hypophosphatemia following parathyroidectomy in chronic hemodialysis patients

Linda Shavit, Meyer Lifschitz, Itzchak Slotki

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background and objectives: Hypoparathyroidism in patients with functioning kidneys leads to hyperphosphatemia. This paper reviews data suggesting that hypoparathyroidism in patients on maintenance dialysis leads to hypophosphatemia. Design: Clinical data in 2 patients on dialysis with hypoparathyroidism following parathyroid surgery; literature review of dialysis patients with hypoparathyroidism following parathyroid surgery. Results: In the patients presented both here and in the literature, hypoparathyroidism in dialysis patients is associated with persistent hypophosphatemia or decrease in serum phosphorus from its pre-surgery level. Conclusion: In patients on maintenance dialysis, persistent hypoparathyroidism post-parathyroidectomy may lead to chronic hypophosphatemia, in contrast to the hyperphosphatemia usually associated with hypoparathyroidism. Proposed mechanisms for this paradoxical phenomenon include ongoing phosphorus deposition into bone (Hungry Bone Syndrome), phosphorus deposition into soft tissue and/or diminished intestinal phosphorus absorption or increased intestinal phosphorus loss.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalClinical Nephrology
Volume78
Issue number5
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Hemodialysis
  • Hypophosphatemia
  • Parathyroidectomy

ASJC Scopus subject areas

  • Nephrology

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