Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal

Wen Ho Chang, Shih Ku Lin, Dong Juiing Juang, Li Chin Chen, Chih Hsien Yang, Wei Herng Hu, Ching Paio Chien, Yui-wing F Lam, Michael W. Jann

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued.Haloperidol and reduced haloperidol plasma concentrations were obtained prior to cessation and at weeks 1, 3, 4, 5, 7, 9, 11, and 13 post-injection. Haloperidol and reduced haloperidol plasma concentrations were assayed by HPLC. Both haloperidol and reduced haloperidol plasma concentrations were detectable 13 weeks post HLD discontinuation. Maximal haloperidol plasma concentrations were observed at one week post cessation and gradually declined. The mean elimination half-life for haloperidol was 27.4 ± 8.6 days (range 19.0- 47.0 days). Reduced haloperidol plasma concentrations declined very slowly. Our results show that both haloperidol and reduced haloperidol plasma concentrations can remain for extended time periods after HLD is discontinued.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalSchizophrenia Research
Volume9
Issue number1
DOIs
StatePublished - 1993

Fingerprint

Decanoates
Haloperidol
Injections
4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol
Half-Life
High Pressure Liquid Chromatography
haloperidol decanoate

Keywords

  • Haloperidol
  • Haloperidol decanoate
  • Reduced haloperidol

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Chang, W. H., Lin, S. K., Juang, D. J., Chen, L. C., Yang, C. H., Hu, W. H., ... Jann, M. W. (1993). Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal. Schizophrenia Research, 9(1), 35-40. https://doi.org/10.1016/0920-9964(93)90007-6

Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal. / Chang, Wen Ho; Lin, Shih Ku; Juang, Dong Juiing; Chen, Li Chin; Yang, Chih Hsien; Hu, Wei Herng; Chien, Ching Paio; Lam, Yui-wing F; Jann, Michael W.

In: Schizophrenia Research, Vol. 9, No. 1, 1993, p. 35-40.

Research output: Contribution to journalArticle

Chang, WH, Lin, SK, Juang, DJ, Chen, LC, Yang, CH, Hu, WH, Chien, CP, Lam, YF & Jann, MW 1993, 'Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal', Schizophrenia Research, vol. 9, no. 1, pp. 35-40. https://doi.org/10.1016/0920-9964(93)90007-6
Chang, Wen Ho ; Lin, Shih Ku ; Juang, Dong Juiing ; Chen, Li Chin ; Yang, Chih Hsien ; Hu, Wei Herng ; Chien, Ching Paio ; Lam, Yui-wing F ; Jann, Michael W. / Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal. In: Schizophrenia Research. 1993 ; Vol. 9, No. 1. pp. 35-40.
@article{c5b32f805c7a4efcad4a6f01834db9c1,
title = "Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal",
abstract = "Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued.Haloperidol and reduced haloperidol plasma concentrations were obtained prior to cessation and at weeks 1, 3, 4, 5, 7, 9, 11, and 13 post-injection. Haloperidol and reduced haloperidol plasma concentrations were assayed by HPLC. Both haloperidol and reduced haloperidol plasma concentrations were detectable 13 weeks post HLD discontinuation. Maximal haloperidol plasma concentrations were observed at one week post cessation and gradually declined. The mean elimination half-life for haloperidol was 27.4 ± 8.6 days (range 19.0- 47.0 days). Reduced haloperidol plasma concentrations declined very slowly. Our results show that both haloperidol and reduced haloperidol plasma concentrations can remain for extended time periods after HLD is discontinued.",
keywords = "Haloperidol, Haloperidol decanoate, Reduced haloperidol",
author = "Chang, {Wen Ho} and Lin, {Shih Ku} and Juang, {Dong Juiing} and Chen, {Li Chin} and Yang, {Chih Hsien} and Hu, {Wei Herng} and Chien, {Ching Paio} and Lam, {Yui-wing F} and Jann, {Michael W.}",
year = "1993",
doi = "10.1016/0920-9964(93)90007-6",
language = "English (US)",
volume = "9",
pages = "35--40",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal

AU - Chang, Wen Ho

AU - Lin, Shih Ku

AU - Juang, Dong Juiing

AU - Chen, Li Chin

AU - Yang, Chih Hsien

AU - Hu, Wei Herng

AU - Chien, Ching Paio

AU - Lam, Yui-wing F

AU - Jann, Michael W.

PY - 1993

Y1 - 1993

N2 - Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued.Haloperidol and reduced haloperidol plasma concentrations were obtained prior to cessation and at weeks 1, 3, 4, 5, 7, 9, 11, and 13 post-injection. Haloperidol and reduced haloperidol plasma concentrations were assayed by HPLC. Both haloperidol and reduced haloperidol plasma concentrations were detectable 13 weeks post HLD discontinuation. Maximal haloperidol plasma concentrations were observed at one week post cessation and gradually declined. The mean elimination half-life for haloperidol was 27.4 ± 8.6 days (range 19.0- 47.0 days). Reduced haloperidol plasma concentrations declined very slowly. Our results show that both haloperidol and reduced haloperidol plasma concentrations can remain for extended time periods after HLD is discontinued.

AB - Haloperidol and reduced haloperidol plasma concentrations were measured in twelve schizophrenic patients upon cessation of haloperidol decanoate (HLD) treatment. Each patient received HLD 100 mg every 4 weeks for five injections. After the fifth injection, HLD was discontinued.Haloperidol and reduced haloperidol plasma concentrations were obtained prior to cessation and at weeks 1, 3, 4, 5, 7, 9, 11, and 13 post-injection. Haloperidol and reduced haloperidol plasma concentrations were assayed by HPLC. Both haloperidol and reduced haloperidol plasma concentrations were detectable 13 weeks post HLD discontinuation. Maximal haloperidol plasma concentrations were observed at one week post cessation and gradually declined. The mean elimination half-life for haloperidol was 27.4 ± 8.6 days (range 19.0- 47.0 days). Reduced haloperidol plasma concentrations declined very slowly. Our results show that both haloperidol and reduced haloperidol plasma concentrations can remain for extended time periods after HLD is discontinued.

KW - Haloperidol

KW - Haloperidol decanoate

KW - Reduced haloperidol

UR - http://www.scopus.com/inward/record.url?scp=0027461179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027461179&partnerID=8YFLogxK

U2 - 10.1016/0920-9964(93)90007-6

DO - 10.1016/0920-9964(93)90007-6

M3 - Article

VL - 9

SP - 35

EP - 40

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1

ER -