Prolactin releasing activity of arginine vasotocin in vitro

M. K. Vaughan, D. E. Blask, L. Y. Johnson, R. J. Reiter

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

A significant elevation in both luteinizing hormone (LH) and prolactin release was observed in the culture medium of hemipituitaries from castrated estrogen progesterone (EP) primed female rats incubated for 5 h with arginine vasotocin (AVT) and luteinizing hormone releasing hormone (LRH) compared to corresponding halves incubated with LRH alone. However, AVT alone did not significantly alter the discharge of LH or prolactin from hemipituitaries of EP treated rats in vitro. Arginine vasopressin, a natural analogue of AVT, inhibited prolactin release using this same model system. Normal male rat hemipituitaries incubated with AVT released significantly more LH and prolactin into the culture medium than did their corresponding halves. A log dose response curve indicated that any dose from 100 ng to 10 μg AVT significantly promoted prolactin release. However, the terminal tripeptide of AVT, Pro Arg Gly (NH2), failed to modify the discharge of LH or prolactin into the culture medium.

Original languageEnglish (US)
Pages (from-to)342-350
Number of pages9
JournalHormone Research
Volume6
Issue number5-6
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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