@article{a51f83fac1c54de7a1eadf4732ffee57,
title = "Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism",
abstract = "Sensory",
keywords = "Female Reproductive Endocrinology, Sensory Neuroscience",
author = "Mayur Patil and Sergei Belugin and Jennifer Mecklenburg and Andi Wangzhou and Candler Paige and Barba-Escobedo, {Priscilla A.} and Boyd, {Jacob T.} and Vincent Goffin and David Grattan and Ulrich Boehm and Gregory Dussor and Price, {Theodore J.} and Akopian, {Armen N.}",
note = "Funding Information: We would like to thank Dr. Dustin Green for advice on the experimental strategy, Dr. Michael Henry for guidance on IHC, Dr. Shivani Ruparel for guidance in analyzing quantitative PCR data, Dr. Florence Boutillon for producing recombinant PRL, and Dr. Pao-Tien Chuang (UC San Francisco, San Francisco, CA) for kindly providing the Calca cre/+−ER mouse line. Single-cell gene expression analysis was performed by Bioanalytic and Single-cell core (BASiC) at UT Health at San Antonio. The BASiC core is supported by the Cancer Prevention Research Institute of Texas (CPRIT; RP150600 ) and the Office of Vice President of Research of UT Health at San Antonio . This work was supported by NINDS /NIH NS102161 (T.J.P and A.N.A.), NIH/ NIGMS GM112747 (A.N.A.), NINDS /NIH NS065926 (T.J.P.), and UT BRAIN Pilot Program ID: 1503083 (G.D. and A.N.A.). Funding Information: We would like to thank Dr. Dustin Green for advice on the experimental strategy, Dr. Michael Henry for guidance on IHC, Dr. Shivani Ruparel for guidance in analyzing quantitative PCR data, Dr. Florence Boutillon for producing recombinant PRL, and Dr. Pao-Tien Chuang (UC San Francisco, San Francisco, CA) for kindly providing the Calcacre/+?ER mouse line. Single-cell gene expression analysis was performed by Bioanalytic and Single-cell core (BASiC) at UT Health at San Antonio. The BASiC core is supported by the Cancer Prevention Research Institute of Texas (CPRIT; RP150600) and the Office of Vice President of Research of UT Health at San Antonio. This work was supported by NINDS/NIH NS102161 (T.J.P and A.N.A.), NIH/NIGMS GM112747 (A.N.A.), NINDS/NIH NS065926 (T.J.P.), and UT BRAIN Pilot Program ID: 1503083 (G.D. and A.N.A.). M.P. conducted a majority of experiments and contributed to manuscript writing and revision; S.B. J.M. C.P. P.A.B. and J.T.B performed certain experiments and analysis; A.W. performed certain experiments and analyzed PCR data and prepared corresponding figures and graphical depictions; V.G. generated human PRL and contributed to experimental design, manuscript writing, and revision; D.G. and U.B. generated Prlr-cre and Prlrfl/fl mouse lines and contributed to experimental design and manuscript revision; G.D. helped with electrophysiology experiments and experimental design and contributed to the manuscript preparation; T.J.P. and A.N.A designed and directed the project, helped with experiments, wrote the first draft of the manuscript, and prepared the final version of the manuscript. All authors declare that they have no competing interests. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = oct,
day = "25",
doi = "10.1016/j.isci.2019.09.039",
language = "English (US)",
volume = "20",
pages = "449--465",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
}