Proinsulin and specific insulin concentration in high-and low-risk populations for NIDDM

S. M. Haffner, R. R. Bowsher, L. Mykkanen, Helen P Hazuda, B. D. Mitchell, R. A. Valdez, R. Gingerich, A. Monterossa, M. P. Stern

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Abstract

Hyperinsulinemia and insulin resistance have been implicated as risk factors for the development of non-insulin-dependent diabetes mellitus (NIDDM). Recent data suggest that proinsulin may comprise a large proportion of immunoreactive insulin in subjects with NIDDM and possibly in those with impaired glucose tolerance (IGT) as well. Increased proinsulin concentrations are thought to be an early indicator of a failing pancreas. We examined proinsulin, insulin (using an assay that does not display appreciable cross- reactivity with proinsulin), and the fasting proinsulin:insulin ratio in 206 nondiabetic Mexican-American (a high-risk population for NIDDM) and 123 nondiabetic non-Hispanic white (a low-risk population for NIDDM) participants in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular disease. Mexican-Americans had significantly higher fasting and 2-h proinsulin and insulin levels but similar fasting proinsulin:insulin ratios compared with non-Hispanic whites. After statistical adjustment for age, body mass index, waist-to-hip ratio, and glucose tolerance status, Mexican-Americans continued to have higher fasting and 2-h insulin and fasting and 2-h proinsulin concentrations but similar proinsulin:insulin ratios compared with non-Hispanic whites. The fasting proinsulin:insulin ratio was higher in 85 subjects with NIDDM compared with subjects with IGT or normal glucose tolerance (0.31, 0.09, and 0.07, respectively). Thus, nondiabetic subjects from a high-risk population for NIDDM are hyperinsulinemic (using an assay that does not cross-react with proinsulin) and, further, do not secrete more proinsulin relative to insulin itself than do nondiabetic subjects from a low-risk population.

Original languageEnglish (US)
Pages (from-to)1490-1493
Number of pages4
JournalDiabetes
Volume43
Issue number12
StatePublished - 1994

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Proinsulin
Type 2 Diabetes Mellitus
Insulin
Population
Fasting
Glucose Intolerance
Glucose
Waist-Hip Ratio
Hyperinsulinism
Insulin Resistance
Pancreas
Body Mass Index
Cardiovascular Diseases

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Haffner, S. M., Bowsher, R. R., Mykkanen, L., Hazuda, H. P., Mitchell, B. D., Valdez, R. A., ... Stern, M. P. (1994). Proinsulin and specific insulin concentration in high-and low-risk populations for NIDDM. Diabetes, 43(12), 1490-1493.

Proinsulin and specific insulin concentration in high-and low-risk populations for NIDDM. / Haffner, S. M.; Bowsher, R. R.; Mykkanen, L.; Hazuda, Helen P; Mitchell, B. D.; Valdez, R. A.; Gingerich, R.; Monterossa, A.; Stern, M. P.

In: Diabetes, Vol. 43, No. 12, 1994, p. 1490-1493.

Research output: Contribution to journalArticle

Haffner, SM, Bowsher, RR, Mykkanen, L, Hazuda, HP, Mitchell, BD, Valdez, RA, Gingerich, R, Monterossa, A & Stern, MP 1994, 'Proinsulin and specific insulin concentration in high-and low-risk populations for NIDDM', Diabetes, vol. 43, no. 12, pp. 1490-1493.
Haffner SM, Bowsher RR, Mykkanen L, Hazuda HP, Mitchell BD, Valdez RA et al. Proinsulin and specific insulin concentration in high-and low-risk populations for NIDDM. Diabetes. 1994;43(12):1490-1493.
Haffner, S. M. ; Bowsher, R. R. ; Mykkanen, L. ; Hazuda, Helen P ; Mitchell, B. D. ; Valdez, R. A. ; Gingerich, R. ; Monterossa, A. ; Stern, M. P. / Proinsulin and specific insulin concentration in high-and low-risk populations for NIDDM. In: Diabetes. 1994 ; Vol. 43, No. 12. pp. 1490-1493.
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