Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Aaron M. Abarbanell; Arthur C. Coffey; John W. Fehrenbacher; Daniel J. Beckman; Jeremy L. Herrmann; Brent Weil; Daniel R. Meldrum

doi:10.1016/j.athoracsur.2009.02.093

Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Aaron M. Abarbanell, Arthur C. Coffey, John W. Fehrenbacher, Daniel J. Beckman, Jeremy L. Herrmann, Brent Weil, Daniel R. Meldrum

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

Original language	English (US)
Pages (from-to)	1036-1043
Number of pages	8
Journal	Annals of Thoracic Surgery
Volume	88
Issue number	3
DOIs	https://doi.org/10.1016/j.athoracsur.2009.02.093
State	Published - Sep 2009
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine
Surgery

Access to Document

10.1016/j.athoracsur.2009.02.093

Cite this

@article{92e94b798ef944e8b7964c794e0ed958,

title = "Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart",

abstract = "Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.",

author = "Abarbanell, {Aaron M.} and Coffey, {Arthur C.} and Fehrenbacher, {John W.} and Beckman, {Daniel J.} and Herrmann, {Jeremy L.} and Brent Weil and Meldrum, {Daniel R.}",

note = "Funding Information: This work was supported in part by the United States National Institutes of Health (NIH) R01GM070628, NIH R01HL085595, NIH K99/R00 HL0876077, NIH 1F32HL092718, NIH 1F32HL092719, American Heart Association Grant-in-Aid, and the American Heart Association Post-Doctoral Fellowship 0725663Z.",

year = "2009",

month = sep,

doi = "10.1016/j.athoracsur.2009.02.093",

language = "English (US)",

volume = "88",

pages = "1036--1043",

journal = "Annals of Thoracic Surgery",

issn = "0003-4975",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

AU - Abarbanell, Aaron M.

AU - Coffey, Arthur C.

AU - Fehrenbacher, John W.

AU - Beckman, Daniel J.

AU - Herrmann, Jeremy L.

AU - Weil, Brent

AU - Meldrum, Daniel R.

N1 - Funding Information: This work was supported in part by the United States National Institutes of Health (NIH) R01GM070628, NIH R01HL085595, NIH K99/R00 HL0876077, NIH 1F32HL092718, NIH 1F32HL092719, American Heart Association Grant-in-Aid, and the American Heart Association Post-Doctoral Fellowship 0725663Z.

PY - 2009/9

Y1 - 2009/9

N2 - Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

AB - Mesenchymal stem cells (MSCs) hold great promise for improving myocardial recovery after ischemia. The cardiothoracic surgeon is uniquely positioned to be at the forefront of any clinical application of this therapy. As such, a basic understanding of stem cells and the cytokines that affect stem cell function will be an essential component of the surgeon's ever-expanding knowledge base. This review provides: (1) a general overview of stem cells and MSCs in particular, (2) critically analyzes several cytokines known to alter MSC function, and (3) discusses methods to manipulate cytokine-activated MSCs to improve MSC function for potential clinical application.

UR - http://www.scopus.com/inward/record.url?scp=68849109142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68849109142&partnerID=8YFLogxK

U2 - 10.1016/j.athoracsur.2009.02.093

DO - 10.1016/j.athoracsur.2009.02.093

M3 - Review article

C2 - 19699961

AN - SCOPUS:68849109142

SN - 0003-4975

VL - 88

SP - 1036

EP - 1043

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 3

ER -

Proinflammatory Cytokine Effects on Mesenchymal Stem Cell Therapy for the Ischemic Heart

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this