Progressive increases in serum catalase activity in advancing human immunodeficiency virus infection

Jonathan A. Leff, Martha A. Oppegard, Tyler J. Curiel, Kevin S. Brown, Robert T. Schooley, John E. Repine

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We found that serum from individuals with Acquired Immunodeficiency Syndrome (AIDS) had more (p < .05) catalase activity (31.5 ± 5.2 U/ml) than serum from healthy control subjects (7.3 ± 0.8 U/ml). Moreover, serum catalase (but not glutathione peroxidase) activity increased progressively with advancing human immunodeficiency virus (HIV) infection (i.e., AIDS > symptomatic infection > asymptomatic infection > controls). Increases in serum catalase activity correlated with increases in serum hydrogen peroxide (H2O2) scavenging ability and reached levels which decreased exogenous H2O2-mediated injury to cultured endothelial cells without altering neutrophil bactericidal activity or mononuclear cell cytotoxicity in vitro. Serum catalase activity correlated with serum lactate dehydrogenase (LDH) activity but did not appear to be a consequence of erythrocyte (RBC) hemolysis since RBC fragility and serum haptoglobin levels were comparable in HIV-infected and control subjects. Increases in serum catalase activity may reflect and/or compensate for systemic glutathione and other antioxidant deficiencies in HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalFree Radical Biology and Medicine
Volume13
Issue number2
DOIs
StatePublished - Aug 1992
Externally publishedYes

Keywords

  • Acquired immunodeficiency syndrome
  • Antioxidants
  • Catalase
  • Free radicals
  • Human immunodeficiency virus
  • Hydrogen peroxide
  • Infection
  • Oxygen radicals

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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