Progress report on the stimulant-depressant abuse liability evaluation project

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The Committee on Problems of Drug Dependence has initiated a provisional program for the assessment of abuse liability of compounds with depressant or stimulant profiles. Currently, the program is evaluating a set of methods that may be applied in the future to the open assessment of compounds in animals. The Committee has agreed to proceed with this provisional program to evaluate its feasibility for open evaluation of compounds. The compounds that have been evaluated so far have been solicited by the stimulant-depressant committee. The initial pair of compounds was selected to provide an assessment of reliability of result and to characterize a new agent with the procedures used in the laboratories. The initial approach was to submit two compounds under blind procedures (designated CPDD 1 and 2); the laboratories would use procedures that they considered relevant to abuse liability assessment of the compounds. The overall objective to be met at some point in the future is the selection of an optimal set of procedures that will complement each other in providing the appropriate preclinical assessment of abuse liability of unknown compounds in animals.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalNIDA Research Monograph Series
VolumeNO. 49
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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