TY - JOUR
T1 - Progress in prostate cancer chemoprevention
T2 - Modulators of promotion and progression
AU - Lieberman, Ronald
AU - Bermejo, Carlos
AU - Akaza, Hideyuki
AU - Greenwald, Peter
AU - Fair, William
AU - Thompson, Ian
N1 - Funding Information:
This study was sponsored by an educational grant from AstraZeneca.
Funding Information:
The list of novel agents in the clinic is rapidly expanding because of the identification of new molecular targets (eg, steroid hormone receptors such as ER-alpha, beta, vitamin D receptor), apoptosis cascades (caspases, TRAIL), angiogenesis factors (vascular endothelial growth factor, fibroblast growth factor) and their tyrosine kinase receptors, differentiation pathways (retinoic acid/vitamin D receptors), and oncogene and tumor suppressor gene signaling networks (p53, pten). Targeted molecular pharmacology is guided by the discovery of new genes coming from the Cancer Genome Anatomy Project of the NCI, the high throughput chemical/biologic screening programs supported by the NCI, and the pharmacogenomic screens employed by the pharmaceutical industry. 5
PY - 2001
Y1 - 2001
N2 - Progress in chemopreventive agent development for prostate cancer is guided by identification of new molecular targets through high throughput functional genomic screens and empirical evidence derived from epidemiologic studies, experimental models, and unexpected results from randomized primary prevention trials. More than a dozen agent classes with potential for prostate cancer prevention are in clinical development, including natural products, with many more novel classes expected in the near future (epidermal growth factor receptor inhibitors, proteosome inhibitors, etc.). Suitable study cohorts for definitive prevention trials can be identified and represent potential therapeutic niches for new agent registrations. However, the failure to identify and validate noninvasive surrogate endpoints that predict cancer incidence reduction is a major rate-limiting step thwarting the design and conduct of efficient clinical prevention trials for prostate cancer and the active participation of the pharmaceutical industry.
AB - Progress in chemopreventive agent development for prostate cancer is guided by identification of new molecular targets through high throughput functional genomic screens and empirical evidence derived from epidemiologic studies, experimental models, and unexpected results from randomized primary prevention trials. More than a dozen agent classes with potential for prostate cancer prevention are in clinical development, including natural products, with many more novel classes expected in the near future (epidermal growth factor receptor inhibitors, proteosome inhibitors, etc.). Suitable study cohorts for definitive prevention trials can be identified and represent potential therapeutic niches for new agent registrations. However, the failure to identify and validate noninvasive surrogate endpoints that predict cancer incidence reduction is a major rate-limiting step thwarting the design and conduct of efficient clinical prevention trials for prostate cancer and the active participation of the pharmaceutical industry.
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U2 - 10.1016/S0090-4295(01)01416-9
DO - 10.1016/S0090-4295(01)01416-9
M3 - Review article
C2 - 11744441
AN - SCOPUS:0035667260
VL - 58
SP - 835
EP - 842
JO - Urology
JF - Urology
SN - 0090-4295
IS - 6
ER -